Hepatitis A-hepatitis E combined vaccine and preparation method thereof

Abstract

Disclosed are a combined vaccine for hepatitis A and hepatitis E, and preparation method thereof. Said vaccine comprises hepatitis E virus recombined peoteins, hepatitis A attenuated live vaccine and hepatitis A inactivated vaccine. Said method comprises before the paretion of the final combined vaccine, absorbing hepatitis A attenuated live vaccine viruses and / or hepatitis A inactivated vaccine viruses on aluminum hydroxide gel, absorbing hepatitis E virus recombined peoteins on aluminum hydroxide gel, adjusting the pH value of the two compositons, and mixing the two compositons together. The inventiion is provided with convenience, multiple-effect, low cost, and effective prevention of hepatitis A and hepatitis E for human and animals.

Description

technical field

[0001] The invention relates to a combination vaccine and a preparation method thereof, in particular to a hepatitis A-hepatitis E combination vaccine and a preparation method thereof. Background technique

[0002] In recent years, with the rapid development of my country's economy, the flow of people has increased, and the occurrence of various infectious diseases has become increasingly frequent, which seriously threatens the health of the public and causes a huge economic burden to the country. Therefore, in order to effectively control the prevalence of infectious diseases, research and development of preventive vaccines have important theoretical and practical significance.

[0003] Hepatitis A (Hepatitis A) and Hepatitis E (Hepatitis E) are acute viral hepatitis transmitted through the fecal-oral route. The common forms of hepatitis A and Hepatitis E in my country are epidemic and sporadic. In 1988, the acute hepatitis A epide...