Microflow chip and method for preparing polymer microsphere using same

A technology of microfluidic chips and microspheres, which is applied in the direction of immobilization on/in the organic carrier, block transportation, etc., which can solve the problems that it is difficult for organisms to be damaged, the diameter cannot be precisely controlled, and the distribution of microspheres is large in size, etc. problem, to achieve the effect of uniform size controllable, good shape and good repeatability

Inactive Publication Date: 2006-12-27
WUHAN UNIV
View PDF0 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preparation of polymeric microspheres by traditional methods either cannot precisely control the diameter, or the microspheres have a large size distribution, or require a large amount of reagents
Moreover, these traditional preparation methods make it difficult to ke

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microflow chip and method for preparing polymer microsphere using same

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0018] Example

[0019] 1-3% (mass ratio) sodium alginate and 0.5-5% (mass ratio) calcium chloride are added to the dispersed phase channel, oil is injected from the continuous phase channel, and the dispersed phase is at the input port of the prepolymer microsphere channel At , due to the extrusion of the continuous phase, a stable focused flow is formed, and due to the surface tension, drag force and shear force, the head of the focused flow breaks periodically to produce microspheres of uniform size. In order to achieve different prepolymer solution ratios, the oil speed and prepolymer solution speed can be changed. The flow rate of the prepolymer solution is respectively controlled at 1-2000 microliters / hour, and the flow rate of the oil is always controlled to be higher than the flow rate of the prepolymer solution.

[0020] Prepare sodium alginate and calcium chloride microspheres first: set the flow rate of the oil phase and sodium alginate solution, first use a flow f...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a microflow chip comprising synthesized channel and two beam focusing ball tracks, in which two exits of beam focusing ball tracks converge at the entrance of the synthesized channel, each beam focusing ball track comprises prepolymer microsphere track, discontinuous phase track and two continuous phase channels, the said two continuous phase channels distribute on both sides of the discontinuous phase track, the prepolymer microsphere track, discontinuous phase track and continuous phase channels evenly have ingate and exit and the exits of the discontinuous phase track and continuous phase channels converge at the ingate of the synthesized channel. The invention also provides a method for preparing polymer microsphere using the said microflow chip: injecting two continuous phases from ingates of continuous phase channels of two beam focusing channels, injecting discontinuous phase from discontinuous phase channels of beam focusing channels, then obtaining polymer microsphere from the synthesized channel exit. The invention can exactly prepare controllable polymer microsphere with coincidence sizes.

Description

technical field [0001] The invention relates to a microfluidic chip and a method for preparing polymer microspheres by using the microfluidic chip, in particular to a micromachining design structure, which requires the design to conform to the principle of fluid dynamics, and belongs to the field of microfluidic chips. It can be applied to chemical synthesis to obtain polymer microspheres, which belongs to the field of chemical synthesis. Cells can also be added into biocompatible polymer microspheres to solidify into balls, which can be used as a favorable environment for cell culture, transfer, storage and analysis, and belong to the field of biological cytology. It can also be used in the field of drug sustained release to wrap drugs, and belongs to the field of biopharmaceuticals. Background technique [0002] Controllable polymer microspheres with a diameter of 10-100 μm have attractive potentials in biological, chemical, and medical applications. The traditional prep...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C12N11/08A61K9/16
Inventor 赵兴中刘侃
Owner WUHAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap