Compound fennel capsule for treating indigestion and its prepn process

Abstract

The present invention discloses one kind of compound Tibetan fennel capsule for treating indigestion and its preparation process. The compound Tibetan fennel capsule contains Tibetan fennel oil and mint oil in effective treating amount, the Tibetan fennel oil contains carvol over 50 wt% and limonene over 35 wt%, and the mint oil contains menthol over 25 wt%. The preparation process of the compound Tibetan fennel capsule includes mixing medicine liquid, encapsulating and other steps. The experiments show that medicine of the medicine has determined curative effect, high bioavailability, high safety, high reliability and other features.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and relates to a capsule preparation containing traditional Chinese medicine ingredients, more specifically, a compound Tibetan fennel hard capsule for treating indigestion and a preparation process of the hard capsule. technical background [0002] Tibetan fennel, synonymous as Gongniu and Guoniao (Tibetan medicine name), is the fruit of Umbelliferae planting Artemisia tribute, and its plants are perennial herbs, mainly distributed in Northeast, North China, Northwest, Sichuan, Tibet and other places. Wind medicine and spices are used, called caraway, and it is a commonly used Tibetan medicine in my country. The medicine is warm in nature and slightly pungent in taste. It has the functions of invigorating the stomach, expelling wind and regulating qi. It is used to treat epigastric pain, abdominal pain, indigestion, small intestinal hernia and other diseases. The fruit contain...

AI Technical Summary

Problems solved by technology

[0004] Tibetan fennel oil and peppermint oil are used in combination to treat pain, flatulence, gastrointestinal spasm, etc. caused by functional dyspepsia (FD); although Tibetan fennel oil and peppermint oil have a good effect curative effect, but both belong to the volatile oils of traditional Chinese medicine, which are highly volatile, difficult to store, and easy to deteriorate in the air; and, due to the high content of the main drug, it is difficult to prepare solid preparations. The current better method is to prepare soft capsules

[0005] At present, the combination of Tibetan fennel oil and peppermint oil has Enterplant developed by Dr Will man Schwab GmbH & Co of Germany in medical applications.  Soft capsule products are mainly used for the treatment of functional dyspepsia. They have the same curative effect as Western drug cisapride for gastric motility, and have the advantage of greatly reducing side effects. However, the preparation form of soft capsule has many shortcomings in the preparation of volatile traditional Chinese medicine It is not conducive to the better efficacy of the drug

[0006] Enterplant  The preparation process is to prepare ordinary soft capsules according to the conventional method and then perform enteric coating. The process is relatively complicated and the cost is high. The main problem in the development and production of soft capsule products is the slow disintegration

Soft capsules in the prior art are mainly made of gelatin and glycerin, and the capsule wall layer is relatively thick, some reaching more than 0.5mm, and it is easy to solidify as time increases, and the specific performance is that a layer of membranous substance appears on the inner wall of the capsule shell, making The disintegration time is prolonged, the dissolution rate is reduced or even completely insoluble, which affects the curative effect

Additionally, during stabilization placement, Enterplant  The soft capsule product emits the smell of the contents, indicating that the contents can pass through the capsule shell. The experimental results show that the content of the contents decreases, which proves that the quality of the product is unstable during storage, which affects the efficacy of the product

[0007] To sum up, there are certain problems in the disintegration, absorption and quality stability of the soft capsule products composed of Tibetan fennel oil and peppermint oil in the prior art on the market.