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Production process for removing polycyclic aromatic hydrocarbons from ginkgo leaf extract

A polycyclic aromatic hydrocarbon and production process technology, which is applied in the field of production technology for removing polycyclic aromatic hydrocarbons from ginkgo biloba extracts, can solve environmental pollution, ignore the problem of polycyclic aromatic hydrocarbon residues, and affect the export of ginkgo biloba extracts, etc. problem, to achieve the effect of safe and effective use and residual control

Active Publication Date: 2007-01-10
WUHU LUYE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Ginkgo biloba extract has been widely used in pharmaceuticals, health care products, and food industries. However, due to environmental pollution, the raw materials of ginkgo biloba in many domestic production areas also contain polycyclic aromatic hydrocarbons. Therefore, the current production method of domestic ginkgo leaf extract does not consider the residue of polycyclic aromatic hydrocarbons, which will inevitably affect the medicinal effect of ginkgo leaf extract
However, European and American countries have made strict regulations on the content of polycyclic aromatic hydrocarbons in food. Therefore, if the current domestic production method of ginkgo leaf extract is followed, it will definitely affect the export of ginkgo leaf extract to European countries.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 10kg of Ginkgo biloba extract, add 1000L of methanol aqueous solution with a concentration of 40-50%, heat to 40-50°C, stir and dissolve, leave to cool and filter to obtain the filtrated clear liquid of Ginkgo biloba extract, and transfer the filtrate to a 3000L extraction kettle. Then add 500L cyclohexane, mix evenly, leave to stand for stratification, remove the upper layer of cyclohexane phase, and repeat the extraction of the lower methanol aqueous solution with fresh cyclohexane for 5 times to obtain the alcoholic aqueous solution of Ginkgo biloba extract that has been removed from polycyclic aromatic hydrocarbons , Concentrate the methanol-containing ginkgo leaf extract solution to 100L, then add 100L of pure water and continue to concentrate to 20-50L to control the residual methanol, and dry in a vacuum oven to obtain the ginkgo leaf extract from which polycyclic aromatic hydrocarbons have been removed.

[0016] Measurement results: before removal, the total...

Embodiment 2

[0018] Take 80-100kg of ginkgo biloba extract, add 1000L of ethanol aqueous solution with a concentration of 40-50%, heat to 40-60°C, stir and dissolve, leave to cool and filter to obtain ginkgo biloba extract filtrate clear liquid, and transfer the filtrate to 3000L for extraction kettle, then add 500L cyclohexane, mix uniformly, let stand for layering, remove the upper cyclohexane phase, and repeat the extraction of the lower ethanol aqueous solution with fresh cyclohexane for 7 times to obtain the Ginkgo biloba extract containing polycyclic aromatic hydrocarbons. Alcoholic aqueous solution, the alcoholic aqueous solution is concentrated and spray-dried to obtain the ginkgo leaf extract from which polycyclic aromatic hydrocarbons have been removed.

[0019] Measurement results: before removal, the total amount of PAHs was 82.5ppb, and benzopyrene was 3.1ppb; after removal, the total amount of PAHs was 11.7ppb, and benzopyrene was 0.7ppb.

[0020] The polycyclic aromatic hydr...

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Abstract

The present invention relates to a process capable of utilizing organic solvent to make extraction and remove polycyclic aromatic hydrocarbon from the extract of ginkgo leaf. Said process mainly includes the following several steps: solvating, extraction and drying. As compared with existent technique, the polycyclic aromatic hydrocarbon content in the product can be effectively controlled so as to raise the quality of ginkgo leaf extract.

Description

technical field [0001] The invention relates to a production process for removing polycyclic aromatic hydrocarbons in ginkgo leaf extract. Background technique [0002] Polycyclic aromatic hydrocarbons (PAHs for short) refer to hydrocarbons containing two or more benzene rings in the molecule, which can be divided into aromatic fused ring type and aromatic non-fused ring type. Aromatic fused ring type refers to the hydrocarbons in which the adjacent benzene rings in the molecule have at least two shared carbon atoms, such as naphthalene, anthracene, phenanthrene, pyrene, etc.; aromatic non-fused ring type refers to the adjacent benzene rings in the molecule Only one carbon atom is connected between compounds, such as biphenyl, terphenyl, etc. [0003] PAHs can cause cancer. Chemical carcinogenesis refers to the process in which chemicals cause normal cells to transform and develop into tumors. Chemical carcinogens can be divided into direct carcinogens and indirect carcino...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P9/10A61P25/00A61P11/06A61P39/06A61P3/06
Inventor 曹礼群李五洲蒋永红王建
Owner WUHU LUYE PHARMA
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