Schefflera venulosa extract and use in producing medicine

A technology of Liriodendron miltiorrhiza and extracts, which is applied in the directions of pharmaceutical formulation, drug combination, drug delivery, etc., can solve the problems of unsystematic research on chemical components, unclear components of curative effect, etc., and achieve strong pharmacological effects and good medicinal use. Foreground effect

Inactive Publication Date: 2007-01-24
YUNNAN INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing pharmaceutical preparations belonging to other species are mainly preparations prepared from crude extracts, the research on chemical components is not systematic, and the components that play a curative effect are not clear

Method used

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  • Schefflera venulosa extract and use in producing medicine
  • Schefflera venulosa extract and use in producing medicine
  • Schefflera venulosa extract and use in producing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Embodiment 1: extract preparation

[0065] Take 1000 grams of dried whole plant of Scherichia cheiferae, crush it into a coarse powder, add 10 times the amount of 75% ethanol to reflux and extract three times, the first time is 3 hours, the second time is 2 hours, the third time is 2 hours, filter, and the filtrate is recovered After ethanol, add acid to adjust the pH value to 3-5, pass through a macroporous adsorption resin column, elute with water first, and then elute with 55-70% ethanol, take the eluting part of alcohol, concentrate and dry, crush to obtain yellow-brown powdered extract.

Embodiment 2

[0066] Embodiment 2: tablet preparation

[0067] Get 100g of the extract of the present invention, 80g of starch, and 5g of dextrin and mix evenly, add 10% starch slurry to make soft material, granulate with 14 mesh nylon, ventilate and dry at 60-70°C, granulate with 16 mesh sieve, add stearic acid 1.5g of magnesium and 5g of sodium carboxymethyl starch were mixed evenly, pressed into 1000 tablets, and coated. Each tablet contains 100mg of extract. Adults take orally 2-5 times a day, 1-10 tablets each time.

Embodiment 3

[0068] Embodiment 3: capsule preparation

[0069] Get 100g of the extract of the present invention, add 78g of starch and 2g of magnesium stearate and mix evenly, directly fill 1000 capsules with a full-automatic capsule filling machine, and polish to get final product. Each capsule contains 100mg of extract. Adults take orally 2-5 times a day, 1-10 capsules each time.

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PUM

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Abstract

The present invention is schefflera venulosa extract and its preparation process and use in preparing medicine. The schefflera venulosa extract contains mainly caffeoyl acids 5-40 wt%, quercetin glycoside 15-55 wt% and oleanolic acid glycoside 15-45 wt%. The schefflera venulosa extract may be prepared into orally taken preparation or injection alone or together with pharmaceutically acceptable supplementary material, and the medicine preparation may be used in promoting blood circulation to disperse blood clots, improving microcirculation, and preventing and treating acute myocardial ischemia, coronary heart disease, angina pectoris and other cardiac and cerebral vascular diseases.

Description

technical field [0001] The invention relates to an extract of an effective part of a plant, a preparation method of the extract of the effective part and an application in the field of pharmacy. Background technique [0002] Schefflera venulosa Wight et Arn. is a plant of the genus Schefflera in Araliaceae. Evergreen small tree, 5-7 meters high, palmate compound leaves, 5-7 leaflets, elliptic, 5-10 cm long, 2.5-4 cm wide, apex short and acuminate, base round to slightly cordate, Margin entire, petiole 2-4 cm long. The panicle is about 15 cm long; the flowers are white, fragrant, and the pedicel is obvious. Berry spherical, dark purple when ripe. Recorded in "Yunnan Drug Standards 1974 Edition". It has the effects of relieving pain and detumescence, relaxing tendons and activating collaterals, and is used for rheumatic ostalgia and headache. Distributed in central, southwestern, southeastern, southern and northwestern Yunnan, Guizhou, western Hunan, etc. There are 37 sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/216A61K31/366A61K9/48A61K9/20A61K9/08A61K9/19A61P9/10
Inventor 朱兆云王京昆彭玲芳崔涛尚建华徐榕雪苏敏孙敏
Owner YUNNAN INST OF MATERIA MEDICA
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