Hydrocortisone clyster agent and method for preparing the same

A technology of enema and cortisone, which is applied in the field of hydrocortisone enema and its preparation, can solve the problems of high price and achieve the effects of low price, convenient use and high price ratio

Inactive Publication Date: 2007-02-07
SUZHOU MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is only imported mesalazine enema on the market at present, its main component is 5-aminosalicylic acid, the price is very expensive, and each 60ml enema needs to cost 200 yuan, and it will be used 1-2 times a day. After 6-8 weeks, gradually reduce the dosage to maintain the application; therefore, the vast majority of patients in China cannot afford the cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment one: a kind of hydrocortisone enema, mixed by purified water solvent and active ingredient, wherein, in every 6000ml enema, active ingredient is:

[0053] Hydrocortisone 10.0g;

[0054] Tween-80 12.9g;

[0055] CMC-Na 90.0g;

[0056] Ethylparaben 2.4g.

[0057] Prepared using the following process steps:

[0058] (1), formulating and preparing a total amount of 6000ml, preparing hydrocortisone 10.0g, Tween-80 12.9g, CMC-Na90.0g, ethylparaben 2.4g and purified water;

[0059] (2), use a 1000ml measuring cup to fill 500ml (about 8.3% of the total preparation), add Tween-80 12.9g to it, stir and dissolve;

[0060] (3), add hydrocortisone 10.0g again in the solution obtained in above-mentioned step (2), fully stir;

[0061] (4), in addition, use the purified water of 300ml (5% of the total amount of the preparation) in a beaker, add ethylparaben 2.4g therein, boil, pour into the above-mentioned 1000ml measuring cup after dissolving, and the above-mentioned s...

Embodiment 2

[0064] Embodiment two: a kind of hydrocortisone enema, mixed by purified water solvent and active ingredient, wherein, in every 6000ml enema, active ingredient is:

[0065] Hydrocortisone 10.8g;

[0066] Tween-80 14.0g;

[0067] CMC-Na 85.0g;

[0068] Ethylparaben 2.3g.

[0069] Prepared using the following process steps:

[0070] (1), formulate and prepare the total amount to be 6000ml, prepare hydrocortisone 10.8g, Tween-80 14.0g, CMC-Na85.0g, ethylparaben 2.3g and purified water;

[0071] (2), use a 1000ml measuring cup to fill 450ml (about 7.5% of the total preparation), add Tween-80 14.0g, stir and dissolve;

[0072] (3), add hydrocortisone 10.8g again in the solution obtained in above-mentioned step (2), fully stir;

[0073] (4), in addition, use the purified water of 270ml (4.5% for preparing the total amount) in a beaker, add ethylparaben 2.3g therein, boil, pour in the measuring cup of above-mentioned 1000ml again after dissolving, and above-mentioned steps ( 3)...

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PUM

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Abstract

The invention discloses a loosening enema and preparing method of kao hydrate, which comprises the following parts in each 6000ml: 9.0-11.0g kao hydrate, 11.6-14.2g Tween-80, 81.0-99.0g CMC-Na, 2.1-2.7g aethylum hydroxybenzoicum and pure water. the preparing method comprises the following steps: allocating 7.2-8.8% Tween-80; stirring; dissolving; adding kao hydrate to stir evenly; allocating 4.5-5.5% aethylum hydroxybenzoicum; boiling; adding CMC-Na; bulking; adding purified water to stir evenly.

Description

technical field [0001] The invention relates to an enema and a preparation method thereof, in particular to a hydrocortisone enema for treating ulcerative rectum and sigmoid colitis and a preparation method thereof. Background technique [0002] Ulcerative colitis (ulcerative colitis) has been listed by the World Health Organization as one of the modern refractory diseases. ) of continuous inflammation, its clinical features are recurrent diarrhea (mucus pus and blood in the stool) and abdominal pain, and may be accompanied by systemic symptoms such as fever or joint pain. This disease is difficult for a radical cure, often protracted and difficult to heal, and the course of disease is long, brings great misery to the patient. In recent years, the incidence rate in our country has increased significantly, and the incidence is showing a younger trend, and there is a certain rate of cancer in the chronic phase. [0003] At present, sulfasalazine (SASP) is often used for such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/573A61K47/34A61P1/04A61K47/26
Inventor 郑家驹高志昕薛苏冬贾黎明王毓明
Owner SUZHOU MUNICIPAL HOSPITAL
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