Soft capsule of Rabdosia rubescens, and its prepn. method

Inactive Publication Date: 2007-02-14
河南百年康鑫药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For above-mentioned situation, the purpose of the present invention is exactly to provide a kind of soft capsule and preparation method thereof, to solve the defect that the main active ingredient A in the existing Oridonium tablet and syrup is very little, improve Oridinus preparation The content of the main active ingredients in the drug ensures its clinical efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0012] Take 30kg of Cordyceps japonicus, crush it into a coarse powder, add 8 times the amount of ethanol to 240ml in a tank, heat and pressurize, extract for 15 hours under a pressure of 0.15mPa, collect the extract, recover the ethanol and continue to concentrate to a specific gravity of 1.15 at 60°C. The thick cream, through spray drying, receives fine cream powder 2044g, adds 3600g peanut oil, 178g beeswax, 178g Tween-80, mixes through colloid mill, makes 10000 soft capsules, each 0.6g, gets final product.

example 2

[0014] Take 30kg of Cordyceps japonicus, crush it into a coarse powder, add 9 times the amount of ethanol in the tank, heat and pressurize, the pressure is 0.15mPa, extract for 18 hours, collect the extract, recover the ethanol and continue to concentrate to 60 ° C to measure the specific gravity of 1.3. Ointment, oven dry, pulverize, get fine ointment powder 2100g, add 3580g sesame oil, 168g beeswax, 16g Tween-80, mix through homogenizer, make 10000 soft capsules, each 0.6g, to obtain final product.

example 3

[0016] Take 30kg of Cordyceps japonicus, crush it into a coarse powder, add 10 times the amount of ethanol into the tank, heat and pressurize at a pressure of 0.15mPa, and extract for 16 hours. Paste, dry, pulverize to get extract powder 2090g, add 3570g soybean oil, 170g beeswax, 170g Tween-80 and mix evenly, make 10000 soft capsules, each 0.6g, to get final product.

[0017] Clinical situation:

[0018] 1. Clinical data

[0019] The cases were all outpatients with acute pharyngitis, a total of 108 cases, including 63 cases in the treatment group and 45 cases in the control group. There was no significant difference in gender and age between the two groups.

[0020] 2. Diagnostic criteria

[0021] (1) Western medicine diagnosis;

[0022] 1. Symptoms, main symptoms: sore throat or dysphagia, dry throat, burning. Secondary symptoms: general discomfort, fever, chills, sore limbs, loss of appetite.

[0023] 2. Check, a. Pharyngeal mucosa is congested and bright red.

[0024...

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PUM

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Abstract

A blushred rabdosia herb soft capsule with high content of active component and stability is prepared from the powdered extract of blushred rabdosia herb, plant oil, beeswax and tween-80. Its preparing process is also disclosed.

Description

1. Technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a Donglingcao soft capsule and a preparation method thereof. 2. Background technology [0002] Dongling grass is the dry above-ground part of the Lamiaceae Camellia plant. It has the effects of dispelling wind and relieving heat, detoxifying and relieving sore throat, reducing swelling and relieving pain. Five kinds of diterpenoids were isolated from the ether extract of Rubescens fragrans leaves, namely, Rubescens fragrans A, B, C, D and pentasin, all of which are tetracyclic diterpenoids of Kaurene skeleton type. At present, common preparations of Rubescens japonicus are tablets and syrups, which are used to treat acute and chronic tonsillitis, pharyngitis, laryngitis, stomatitis and other diseases, but the curative effect of the above preparations is not good. The main active ingredients in Rubescens japonicus are Rubescensine A, B, ursolic acid and oleanolic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/48A61P11/04A61P1/02
Inventor 杨士伟蔡俊安王云东郭鑫慧鲁张彦丁永志
Owner 河南百年康鑫药业有限公司
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