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Pharmaceutical composition of ligustrazine and notoginsen triterpenes

A technology of Panax notoginseng saponins and a composition, which is applied in the field of medicine and achieves the effects of wide application prospect, high safety and simple preparation process

Inactive Publication Date: 2007-03-14
蔡军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using the interaction of Panax notoginseng saponins and ligustrazine, there are no reports on the medicines for the treatment of cardiovascular and cerebrovascular diseases with compatible prescriptions.

Method used

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  • Pharmaceutical composition of ligustrazine and notoginsen triterpenes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1: the preparation of this composition water injection

[0071] prescription:

[0072] Ligustrazine Phosphate 50g

[0073] Panax notoginseng saponins 150g

[0074] Propylene glycol 400ml

[0075] Add water for injection to 5000ml

[0076] A total of 1000 sticks were prepared

[0077] Preparation Process:

[0078]1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0079] 2) Ligustrazine phosphate is added to water for injection with a dosing volume of 40% to dissolve completely, and total saponins of Panax notoginseng are added to propylene glycol, heated and stirred to dissolve completely.

[0080] 3) Combine the above solutions and add water for injection to the full amount.

[0081] 4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0082] 5) Decarburization by sand filter stick filtration. Measure and adjust...

Embodiment 2

[0089] The preparation of embodiment 2 this composition powder injection

[0090] prescription:

[0091] Ligustrazine Phosphate 50g

[0092] Panax notoginseng saponins 150g

[0093] Polysorbate 80 100g

[0094] Mannitol 400g

[0095] Add sterile water for injection to 5000ml

[0096] A total of 1000 sticks were prepared

[0097] Preparation Process:

[0098] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0099] 2) Weigh the raw and auxiliary materials according to the prescription quantity.

[0100] 3) Polysorbate 80 is made into a 20% aqueous solution, the total saponins of Panax notoginseng are heated and stirred to dissolve completely, and ligustrazine phosphate is added into sterile water for injection with a dosing volume of 20% to dissolve completely. Mannitol is added with 40% sterile water for injection, heated and stirred to dissolve completely, the above solutions are combined, and ste...

Embodiment 3

[0108] Embodiment 3 The preparation of this composition sodium chloride injection

[0109] prescription:

[0110] Ligustrazine Phosphate 50g

[0111] Panax notoginseng saponins 150g

[0112] Polysorbate 80 100g

[0113] Sodium chloride 900g

[0114] Add water for injection to 100000ml

[0115] A total of 1000 bottles were prepared

[0116] Preparation Process:

[0117] 1) Dispose of the pipes and containers used for liquid preparation the day before, and rinse them with fresh water for injection before use.

[0118] 2) Polysorbate 80 is prepared into a 20% aqueous solution, the total saponins of Panax notoginseng are added with heating and stirred to dissolve completely, and ligustrazine phosphate is added into water for injection with a dosing volume of 20% to dissolve completely. Dissolve the sodium chloride completely with water for injection with a dosing volume of 40%.

[0119] 3) Combine the above solutions and add water for injection to the full amount.

[0120...

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Abstract

Disclosed is a pharmaceutical composition, its preparing method and use, wherein the composition comprises ligustrazine or its pharmaceutically acceptable salts and panax notoginseng saponins, the range of the weight ratio of the two constituents is 1:0.1-50. The two ingredients can be used individually or mixed with medicinal auxiliary materials to obtain clinically and pharmaceutically acceptable dose forms including injections, constant release oral dosage forms, slow release and controlled release dosage forms, granules, pills, and oral liquid preparations.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition containing ligustrazine or a pharmaceutically acceptable salt thereof and Panax notoginseng saponins, a preparation containing the pharmaceutical composition or a preparation method thereof. [Background technique] [0002] In recent years, as our country has gradually stepped into an aging society, people's living standards have improved, the pace of life has accelerated, and eating habits have developed towards high fever and high fat. Cardiovascular diseases such as heart disease and stroke have become a threat to human health and life. It is one of the most serious diseases and one of the important causes of serious disability and death of human beings. Therefore, to reveal the mechanism of the occurrence and development of cardiovascular and cerebrovascular diseases, to carry out effective prevention, treatment and rehabilitation, and to reduce d...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K31/704A61P7/02A61P9/10A61K31/4965
Inventor 蔡军
Owner 蔡军
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