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Composition of barrenwort extract and puerarin, preparation process and use thereof

A technology of epimedium extract and composition, applied in the field of medicine, to achieve high safety, prevention of atherosclerosis, and definite curative effect

Inactive Publication Date: 2007-03-14
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, using the interaction between Epimedium extract and Puerarin, compatible prescriptions, to prepare drugs for the treatment of cardiovascular and cerebrovascular diseases, etc., has not yet been reported.

Method used

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  • Composition of barrenwort extract and puerarin, preparation process and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Preparation and identification and content determination of the epimedium extract of embodiment 1 (1)

[0169] Preparation of Epimedium Extract

[0170] Take 1000g of Epimedium, cut into small pieces, add water to decoct 2 times, each time for 1.5 hours, each time add water to 10L. Combine the decoctions, put them in cold storage overnight, filter, concentrate the filtrate to a concentrated solution with a relative density of 1.08 to 1.10, add it to the treated polyamide resin column, wash it with 3 to 4 times the column volume of water, and then wash it with 2 Rinse with 20% ethanol for ~3 times the column volume, discard the washing solution, and then elute with 95% ethanol for 4 to 5 times the column volume, collect the eluate, recover the ethanol, and spray dry to obtain the product.

[0171] Three batches of Epimedium extract were prepared according to the above method, and the yields are shown in Table 8.

[0172] Identification of Epimedium Extract

[0173]Tak...

Embodiment 2

[0185] Preparation and Identification and Content Determination of Example 2 Epimedium Extract (two)

[0186] Preparation of Epimedium Extract

[0187] Take 1000g of Epimedium medicinal material, crush it into medium powder, add 12 times the amount of 70% ethanol, soak for 12 hours, filter, and use the filtrate for later use; add 70% ethanol to heat and extract three times, each time for 1.5 hours, filter, and combine the filtrate , the filtrate was concentrated under reduced pressure to 1000ml, put on the treated polyamide column, first eluted with 15L of distilled water, then eluted with 3L of 15% ethanol, and finally eluted with 20L of 70% ethanol, collected the 70% ethanol eluate, Recover ethanol under reduced pressure and dry it in vacuum to obtain the product.

[0188] Three batches of Epimedium extract were prepared according to the above method, and the yields are shown in Table 9.

[0189] Identification of Epimedium Extract

[0190] According to the identification...

Embodiment 3

[0194] Embodiment 3 The preparation of pharmaceutical composition injection of the present invention

[0195] 1. Prescription:

[0196] Prescription 1

[0197] Epimedium Extract 200g

[0198] Puerarin 200g

[0199] Propylene glycol 700ml

[0200] Add water for injection to 5000ml

[0201] A total of 1000 sticks were prepared

[0202] Prescription 2

[0203] Epimedium Extract 100g

[0204] Puerarin 200g

[0205] Propylene glycol 700ml

[0206] Add water for injection to 5000ml

[0207] A total of 1000 sticks were prepared

[0208] Prescription 3

[0209] Epimedium Extract 200g

[0210] Puerarin 40g

[0211] Propylene glycol 700ml

[0212] Add water for injection to 5000ml

[0213] A total of 1000 sticks were prepared

[0214] Prescription 4

[0215] Epimedium Extract 200g

[0216] Puerarin 20g

[0217] Propylene glycol 700ml

[0218] Add water for injection to 5000ml

[0219] A total of 1000 sticks were prepared

[0220] Prescription 5

[0221] Epimedium ...

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Abstract

The invention relates to a new compound medicine and the preparative way of it, which has something to do with the medicine technology. The compound medicine is the mixture of Epimedium extracts and kakkonein, the ratio of the two ingredients is 1:0.02-50(by weight). The medicine adopts Epimedium extracts and kakkonein as the main material and has a simple producing technology so it can be made into different dosage forms clinically and pharmaceutically acceptable, of which injectable preparation and oral used preparation are the most popular ones; the two medicine cooperate to improve aeteria coronaria circulation, brain microcirculation, microcirculation and blood rheology as well as decrease blood pressure, lower blood fat and resist arhythmia. The compound medicine has enforced drug action, exact curative effect and less adverse reaction. It can be used mainly in drugs that can resist cerebrovascular and cardiovascular diseases.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition comprising epimedium extract and puerarin for preparing anti-cardiovascular and cerebrovascular disease drugs, a preparation method and application thereof, and belongs to the technical field of medicine. 2. Background technology [0002] Cardiovascular and cerebrovascular diseases such as coronary heart disease and angina pectoris are one of the main causes of human death. At present, there are many kinds of drugs for the treatment of coronary heart disease, angina pectoris and other cardiovascular and cerebrovascular diseases. Commonly used western medicines include nitroglycerin, isosorbide mononitrate, nifedipine, etc., but there are generally many problems of adverse reactions; traditional Chinese medicine mainly includes compound salvia miltiorrhiza Preparations, Di'ao Xinxuekang, etc., have relatively few toxic and side effects, but the content of active ingredients is low or the half-life...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61P9/10A61K31/7048
Inventor 蔡军
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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