Preparation method of coccidiostat methyl triazon for animal

Abstract

The present invention relates to anticoccidial medicine for animal, and is especially preparation process of methyl triazone as one anticoccidial medicine for animal. The preparation process includes the following steps: 1. reacting phenol and trifluoro monochloro methanethiol in the presence of organic base to prepare p-trifluoro methylthio phenol; 2. diazotizing red color base RL and chloric substitution reaction to prepare 2-methyl-4-nitrochlorobenzene; 3. catalytically synthesizing methyl carbamide with urea and methylamine; 4. reacting p-trifluoro methylthio phenol and 2-methyl-4-nitrochlorobenzene to prepare 3-methyl-4-(4- trifluoro methylthio phenoxy)-nitrobenzene; and 5. reducing 3-methyl-4-(4- trifluoro methylthio phenoxy)-nitrobenzene with nitrogen, acylating with nitrogen, condensating, cyclizing and other reaction to prepare final product methyl triazone. The process has low cost and is perfected.

Description

1. Technical field: [0001] The invention relates to an anticoccidial drug for animals, in particular to a preparation method of the anticoccidial drug methyl triazone for animals. 2. Background technology: [0002] Anticoccidial drug for animals 1-[3-methyl-4-(4-trifluoromethylthiophenoxy)-phenyl]-3-methyl-1,3,5-triazine-2,4, The synthetic method of 6 triketone (methyl triazone) has been disclosed in German Patent DE3516630, (1985) and DE3516631 (1985). In German Patent DE3516630, it has been reported that 3-methyl-4-(4-three The synthesis of fluoromethylthiophenoxy)-aniline is to make 3-methyl-4-(4-trifluoromethylthiophenoxy)-nitrobenzene carry out hydrogenation reduction reaction in organic solution, and the catalyst used It is Raney nickel, the reaction pressure is as high as 90-150 atmospheres, and the requirements for reaction equipment are relatively high. [0003] In German patent DE3516631, it is reported that the synthesis of methyl triazone is 1-methyl-5-[3-methy...

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Problems solved by technology

[0003] In German patent DE3516631, it is reported that the synthesis of methyl triazone is 1-methyl-5-[3-methyl-4-(4 trifluoromethylthiophenoxy group-)-phenyl]-biuret Prepared by reacting with diethyl carbonate, the reaction yield is low, and the use of diethyl carbonate, which is expensive and difficult to recover, makes the cost of methyl triazone products high

In the above two German patents, the preparation methods of three main intermediates p-trifluoromethylthiophenol, 2-methyl-4-nitrochlorobenzene and methylurea were not reported.