Preparation method of coccidiostat methyl triazon for animal
A technology of methyl triazone and anticoccidia, which is applied in the field of preparation of anticoccidial drug methyl triazone for animals, can solve the problems of low reaction yield, high cost, difficult recovery, etc., and achieves improved The effect of reaction yield
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[0016] 1. Preparation of intermediates
[0017] (1) p-Trifluoromethylthiophenol
[0018] 200g of highly active potassium fluoride and 202g of perchloromethanethiol were reacted in sulfolane at 209°C for 1.75 hours, and then reacted at 209-247°C for 3 hours. The reaction product was fractionally distilled to obtain 42 g of trifluorochloromethanethiol.
[0019] Dissolve 18g of phenol and 25g of pyridine in 150ml of chloroform, cool to 0°C, then slowly add 32g of trifluorochloromethanethiol under stirring, and continue stirring for 6 hours after the addition. After the reaction, about 120 ml of chloroform was distilled off. Then 150 ml of diethyl ether was added to the residue, and pyridine hydrochloride was removed by suction filtration. After recovering the solvent, 30.0 g of p-trifluoromethylthiophenol was obtained, with a yield of 72.5% and a purity of 99%.
[0020] (2) Synthesis of 2-methyl-4-nitrochlorobenzene
[0021] Add 1500 ml of hydrochloric acid and 150 g of red ...
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