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Medicine composition of red sage and puerarin

A technology of puerarin and a composition is applied in the preparation field containing the pharmaceutical composition and the preparation field thereof, and achieves the effects of wide application prospect, high safety and simple preparation process

Inactive Publication Date: 2007-03-21
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the use of Danshen and puerarin to interact with each other and combine prescriptions to treat cardiovascular and cerebrovascular diseases has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] The preparation of embodiment 1 salvia miltiorrhiza extract

[0093] 1. Water extraction process screening experiment

[0094] The amount of water added, extraction time and extraction times had a great influence on the extraction results, so the content of total phenolic acids in Salvia miltiorrhiza and the yield of extract were taken as indicators, and the influence of the three factors on the extraction results was investigated by orthogonal experiment method. The factors and level design are shown in Table 4.

[0095] level / factor

A water amount (times)

B Extraction time (hours)

C extraction times (times)

1

18

3

1

2

20

4

2

3

22

5

3

[0096] Experimental method Weigh 100g of Salvia miltiorrhiza, a total of 9 parts, extract according to the requirements of each column number in Table 4, combine the extracts, filter, concentrate the filtrate and dilute to 500ml...

Embodiment 2

[0126] Embodiment 2: Preparation of GD composition powder injection

[0127] prescription:

[0128] Danshen Extract 100g

[0129] Puerarin 100g

[0130] Polysorbate 80 50g

[0131] Mannitol 300g

[0132] Add sterile water for injection to 3000ml

[0133] A total of 1000 sticks were prepared

[0134] Danshen Extract 75g

[0135] Puerarin 150g

[0136] Polysorbate 80 75g

[0137] Mannitol 300g

[0138] Add sterile water for injection to 3000ml

[0139] A total of 1000 sticks were prepared

[0140] Danshen Extract 50g

[0141] Puerarin 150g

[0142] Polysorbate 80 75g

[0143] Mannitol 300g

[0144] Add sterile water for injection to 3000ml

[0145] A total of 1000 sticks were prepared

[0146] Preparation Process:

[0147] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0148] 2) Weigh the raw and auxiliary materials according to the prescription quantity.

[0149] 3) Add the salvia milt...

Embodiment 3

[0157] Embodiment 3: Preparation of GD composition aqueous injection

[0158] prescription:

[0159] Danshen Extract 100g

[0160] Puerarin 100g

[0161] Propylene glycol 700ml

[0162] Add water for injection to 2000ml

[0163] A total of 1000 sticks were prepared

[0164] Danshen Extract 75g

[0165] Puerarin 150g

[0166] Propylene glycol 700ml

[0167] Add water for injection to 2000ml

[0168] A total of 1000 sticks were prepared

[0169] Danshen Extract 50g

[0170] Puerarin 150g

[0171] Propylene glycol 700ml

[0172] Add water for injection to 2000ml

[0173] A total of 1000 sticks were prepared

[0174] Preparation Process:

[0175] 1) Dispose of the pipes and containers used for liquid preparation in one day, and rinse them with fresh water for injection before use.

[0176] 2) Add the salvia miltiorrhiza extract into water for injection with a dosing volume of 20%, heat and stir to dissolve completely. Puerarin was added to propylene glycol and heated...

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PUM

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for treating cardiac and cerebral vascular diseases and its preparations and preparation process. The medicine composition is prepared with red sage in 1500-15000 weight portions and puerarin in 100-1000 weight portions, and may be prepared into different pharmaceutically acceptable forms, preferably injection and orally taken preparation. The medicine composition may be also prepared with red sage extract and puerarin. The medicine composition has greatly raised synergistic effect and high stability.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition made of salvia miltiorrhiza and puerarin, a preparation containing the pharmaceutical composition and a preparation method thereof. [Background technique] [0002] Cardiovascular and cerebrovascular diseases have always been known as the number one killer that threatens human health. According to relevant survey reports, there are more than 3 million people who die from cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of the total number of deaths in my country every year. 75% of people lost their ability to work to varying degrees, and 4% were seriously disabled. In particular, the age of its onset and death is increasingly younger, and how to effectively prevent and treat it has attracted people's attention. [0003] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, ...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/08A61P9/10A61P9/12A61P7/02A61P3/06A61K31/7048
Inventor 蔡军
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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