Puvatadin dropping balls and production thereof
A technology of pravastatin and pravastatin drop pills, which is applied in the field of pravastatin drop pills and its preparation, can solve the problems of mutagenesis and other problems, and achieve the effects of accelerated dissolution and absorption, quick onset of action, and fewer procedures
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Embodiment 1
[0036]The preparation of embodiment 1-pravastatin dropping pills (1)
[0037] Method: take 0.1 g of polyethylene glycol 2000, 13 g of polyethylene glycol 4000, 23.5 g of polyethylene glycol 6000, 0.1 g of polyethylene glycol 8000, 0.1 g of polyethylene glycol 10000, polyoxyl stearate 40 Ester 1g, Beta Cyclodextrin 0.5g, Poloxamer 0.5g, Carboxymethyl Starch Sodium 0.5g, Stearic Acid 0.1g, Sodium Stearate 0.1g, Glycerin Gelatin 0.1g, Monostearic Acid Glyceride 0.1 gram, shellac 0.1 gram, polyoxyethylene monostearate 0.1 gram, polyether 0.1 gram, mix evenly, then add pravastatin raw material powder 10 grams, fully stir and mix evenly, adopt the mode of electric heating The prepared mixture of raw and auxiliary materials is heated to a molten state, and the dripper temperature is adjusted and kept at 85°C (error <2%) using a self-made special pilling machine; The advanced refrigeration control system keeps the temperature of the condensing agent at 20→-5°C (error <5%), and then d...
Embodiment 2
[0039] The preparation of embodiment 2-pravastatin dropping pills (2)
[0040] Method: Take 10 grams of polyethylene glycol 4000, 20 grams of polyethylene glycol 6000, 3 grams of polyoxyl 40 stearate, 6 grams of beta cyclodextrin, and 1 gram of glyceryl monostearate, and mix well , then add 10 grams of pravastatin raw material powder, fully stir and mix evenly, heat the prepared raw and auxiliary material mixture to a molten state by means of electric heating, and use a self-made special dropping pill machine to adjust the dripper temperature and keep it At 85°C (error<2%); use methyl silicone oil as the condensing agent, adjust the refrigeration control system of the dropping pill machine to keep the temperature of the condensing agent at 20→-5°C (error<5%), and then follow the previous preparation process The method given is carried out dripping, takes out after shrinkage molding, removes the surface condensing agent, dries, makes the dripping pill of 50mg of pill weight and...
Embodiment 3
[0042] The preparation of embodiment 3-pravastatin dropping pills (3)
[0043] Method: Take 11 grams of polyethylene glycol 4000 and 29 grams of polyethylene glycol 6000 respectively, mix them evenly, then add 10 grams of pravastatin raw material powder, stir and mix evenly, and use electric heating to heat the prepared raw material mixture Heating to a molten state, using a self-made special dropping pill machine, adjusting the dropper temperature and keeping it at 85°C (error <2%); using methyl silicone oil as a condensing agent, adjusting the refrigeration control system of the dropping pill machine to condense The temperature of the agent was kept at 20→-5°C (error<5%), and then dripped according to the method given in the previous preparation process. After shrinking and molding, it was taken out, the surface condensing agent was removed, and dried to make pellets weighing 50 mg containing The drop pill of medicine 10mg / grain is then carried out the mensuration of roundn...
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