Process for preparing hypericum japonicum extract

A technology of Tianjihuang and its extract is applied in the field of preparation of Tianjihuang extract, which can solve the problems of heavy pollution, large loss of effective components, and low product recovery rate.

Active Publication Date: 2007-04-11
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the traditional Chinese patent medicines are prepared by water extraction and alcohol precipitation process, the total solids and active ingredients of traditional Chinese medicine are lost, the amount of ethanol is large, the product recovery rate is low, the production cycle is long, the production cost is high, the pollution is heavy, and the long-term storage quality of the product is poor. , these deficiencies have affected the efficacy of traditional Chinese medicine products and the development of the traditional Chinese medicine industry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1. Get 1 kilogram of Tianjihuang medicinal material, decoct and extract 3 times, add 15 times of water each time, decoct for 1 hour each time, filter, and combine the filtrates. Four parts of the above-mentioned filtrate were taken respectively, and 10 liters of each part was taken, and filtered with ceramic membranes of different pore sizes. The results are shown in Table 1. Ceramic membranes with different pore sizes can be filtered to obtain a relatively clear solution, but the best effect is 0.2 μm.

[0011] Membrane pore size

Embodiment 2

[0012] Embodiment 2. Weigh 9 parts of Tianjihuang medicinal material in parallel, each part of 2000 grams, take extraction time (A), extraction times (B), water addition (C), organic membrane pore size (D) as investigation factors, to extract The amount of material obtained is the investigation index, and L 9 (3 4 ) Orthogonal table arrangement test. In the experiment, the pore size of the inorganic ceramic membrane was fixed at 0.2 μm, and the final liquid was concentrated to a relative density of 1.10, and the precipitate was dried after standing for 48 hours. The test plan and results are shown in Table 2 and Table 3, respectively.

[0013]

[0014]

[0015] The experimental results show that the total flavonoid content of the extracts obtained under different conditions is higher than 50%; visual analysis shows that: decocting and extracting 3 times, adding 20 times the amount of water each time, and decocting for 1 hour is the best; the pore size of ...

Embodiment 3

[0016] Embodiment 3. Take 1 kilogram of Tianjihuang medicinal material, add water to decoct and extract 3 times, add 20 times of water each time, decoct for 1 hour each time, merge 3 times of decocting extracts, filter with a ceramic filter with a pore size of 0.2 μm Membrane filtration, the filtrate is filtered by an organic ultrafiltration membrane with a molecular weight cut-off of 2000, the filtrate is concentrated to a relative density of 1.05, and placed for 1 hour, the precipitate is separated out, filtered, and the precipitate is dried to obtain 23.8 grams of Tianjihuang extract. The total flavonoid content of the extract was analyzed to be 56.2%.

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PUM

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Abstract

The invention relates to a preparation method for Japanese St. Johnswort extract, and characterized by the following steps: taking Japanese St. Johnswort, the medicinal materials, boiling 1-3 times, each time adding water 5-30 times of said materials, each time boiling for 10min.2 hr., filtering, combining water boiling solution; filtering by ceramic membrane with aperture of 0.1 mum-0.8 mum , again filtering by organic membrane with molecular cut off of 2000-8000, filtrate being concentrated into relative density as 1.05-1.20,laying aside to have sediment, filtering, taking sediment to be dried , thus obtaining said Japanese St. Johnswort extract , the general flavone amount making up more than 50% in said extract.

Description

technical field [0001] The invention relates to a preparation method for preparing Tianjihuang extract. Background technique [0002] Generally speaking, the molecular weight of active ingredients in traditional Chinese medicine is small, most of which do not exceed 1000; substances with large molecular weight are mainly non-medicinal ingredients such as protein, starch, and cellulose, or ingredients with poor medicinal properties. Most of the traditional Chinese patent medicines are prepared by water extraction and alcohol precipitation process, the total solids and active ingredients of traditional Chinese medicine are lost, the amount of ethanol is large, the product recovery rate is low, the production cycle is long, the production cost is high, the pollution is heavy, and the long-term storage quality of the product is poor. , These deficiencies have affected the efficacy of traditional Chinese medicine products and the development of the Chinese medicine industry. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/16A61P1/00A61P43/00A61K127/00
Inventor 苏薇薇田珩王永刚彭维李沛波吴忠
Owner SUN YAT SEN UNIV
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