The pharmaceutical for treatment of vascular lesion through actions on the NEI network

A drug and network technology, applied in cardiovascular system diseases, drug combinations, medical raw materials derived from birds, etc., can solve the problem of unretrieved domestic and foreign literature reports.

Active Publication Date: 2007-04-11
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the analysis of literature in recent years, although the nervous, endocrine, and immune subsystems have been discussed in the pathogenesis and prevention of vascular diseases, there is no report on the use of NEI network theory to study and prevent vascular diseases. The results of searching the Chinese Biomedi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 A class of traditional Chinese medicine that belongs to Rong Yang Collaterals and treats vascular diseases by regulating the NEI network

[0059] Rongyang collaterals medicine is mainly tonic medicine, nourishing and warming collaterals with deficiency of qi, blood, yin and yang, and is mainly used for syndrome of deficiency of collaterals. Such drugs are represented by ginseng, and also include: astragalus, antler, donkey-hide gelatin, sand ginseng, Ophiopogon japonicus, Ziheche, aconite, cinnamon, dried ginger, raw rehmannia, American ginseng, Codonopsis pilosula, Atractylodes macrocephala, yam, licorice, rehmannia glutinosa, Paeoniae Alba, Polygonum multiflorum, Dendrobium, Lycium barbarum, Ligustrum lucidum, Sangjishen, Lingpi, Morinda officinalis, Cistanche, Cuscuta, Eucommia, Dipsacus, Epimedium, Achyranthes bidentata.

[0060] Test representative drug: ginseng

[0061] Experiment title: Effect of ginseng on sympathetic neurotransmitters and renin-angio...

Embodiment 2

[0066] Example 2 A class of traditional Chinese medicine that belongs to the class of flowing qi and smoothing collaterals and treats vascular diseases by regulating the NEI network

[0067] Flowing Qi and smoothing collaterals mainly use pungent herbs to flow Qi and unblock the collaterals. It is mainly used to treat the stagnation of collaterals and qi running in the qi collaterals, and it also has a smooth effect on the blood running in the venation. This kind of medicine is represented by scallions and balsamic, and also includes: frankincense, cinnamon sticks, sandalwood, asarum, musk, borneol, nuxyche, ephedra, inula, mint, mulberry leaves, chrysanthemum, Bupleurum, Cimicifuga, Huoxiang, Peilan, Magnolia officinalis, Chenpi, Qingpi, Woody, Cyperus, Aurantium.

[0068] Test representative drug: Bupleurum

[0069] Experiment title: Effects of Bupleurum bupleuri on the neuroendocrine immune system of hypertensive rats

[0070] Objective: To observe the effect of Bupleurum...

Embodiment 3

[0075] Example 3 A class of traditional Chinese medicine that belongs to the class of removing blood stasis and dredging collaterals and treats vascular diseases by regulating the NEI network

[0076] Drugs for removing blood stasis and dredging collaterals are mainly used for collateral stasis, and their representative drugs include leech, Mildew Spatholobus, and ground beetle, and also include: angelica, peach kernel, horsefly, rhubarb, salvia, chuanxiong, safflower, corydalis, turmeric, Motherwort, Achyranthes bidentata, Panax notoginseng, Wujiapi, Danpi, Yuanhu, frankincense, myrrh, silkworm, water safflower seeds, buliuxing, wulingzhi, yanhusuo.

[0077] Test representative drug: ground beetle

[0078] Experiment title: Effects of ground beetle on vascular endothelial dysfunction in rabbits with experimental atherosclerosis

[0079] Objective: To observe the effect of ground beetle on vascular endothelial dysfunction in rabbits with experimental atherosclerosis;

[0080...

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PUM

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Abstract

This invention provides drugs which are already known to be able to act effectively on informational molecules of the NET and their acceptors or influence informational molecules and their acceptors' signal transduction pathways, and their applications in preparing medicine for angiopathy treatment. The said drugs include single Chinese herbs, compound Chinese herbs and their preparations, chemical effective constituents, medicinal compounds and their preparations, biologic effective constituents, medicinal compounds and materials for their preparations. It also provides a new kind of drugs which can effectively act on the said mutual informational molecules of the NET and their acceptors, or influence their signal transduction pathways so as to treat angiopathy; and furthermore provides these drugs' preparation methods.

Description

technical field [0001] The present invention relates to a class of medicines for the treatment of vascular lesions; more specifically, to a class of information molecules (such as neurotransmitters, neuropeptides, hormones, etc.) , cytokines) and their receptors, or drugs that can affect the signal transduction pathway of shared information molecules and their receptors, thereby treating vascular diseases; and further relate to the preparation methods of these drugs. Background technique [0002] Vascular diseases such as cerebrovascular disease, cardiovascular disease, peripheral vascular disease and diabetic microvascular disease have become major diseases that seriously endanger human health. Among them, cerebrovascular disease and cardiovascular disease are the first and third diseases that cause human death, respectively. According to the "CCEP Project Implementation and Results in 2004", about 2.6 million people die of acute cardiovascular and cerebrovascular diseases ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K45/00A61P9/00A61K35/50A61K35/38A61K35/32A61K35/57
Inventor 吴以岭
Owner HEBEI YILING MEDICINE INST
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