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Synthetic methods for nutame

A synthetic method, neotame technology, applied in chemical instruments and methods, food science, dipeptide, etc., can solve the problems of high production cost, low product purity, complicated process, etc., and achieve low production cost, high product purity, The effect of simple process

Inactive Publication Date: 2007-05-23
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0006] There are many synthetic methods of neotame, each of which has its own advantages, but also has shortcomings, such as low product purity, harsh reaction conditions, complicated process, low yield, high production cost, etc.
The process of producing neotame in this way is too complicated, which is not conducive to industrialization

Method used

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  • Synthetic methods for nutame

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Experimental program
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Effect test

Embodiment 1

[0021] A kind of synthetic method of neotame provided by the invention is made according to the following steps successively:

[0022] ① Preparation of tert-butyl chloride

[0023] Put 7.4g of tert-butanol into a three-necked flask equipped with a stirrer, a water bath, and a straight condenser, and add 7.3g of concentrated hydrochloric acid dropwise with stirring at room temperature. The dropwise addition is completed in 30 minutes, and react at a temperature of 55-60°C until no product is produced. Distilled off to obtain 8.3 g of tert-butyl chloride with a yield of 90%.

[0024] ② Preparation of 3,3-dimethyl-1-chlorobutane (DMCB)

[0025] Transfer 8.3 g of the obtained tert-butyl chloride into a three-necked bottle equipped with a thermometer and a ventilation and exhaust pipe to cool below -10°C, add 0.1 g of ferric bromide powder, feed ethylene gas, and shake the three-necked bottle to start the reaction . Keep the temperature between -7°C and 0°C during the reaction p...

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Abstract

This invention discloses a synthesis method for Neotame. The said method includes the following steps: (1) carrying out a reaction of tert-butanol with hydrochloric acid to obtain tert-butyl chloride; (2) adding catalyst in tert-butyl chloride, and charging ethylene gas and reacting to obtain 3, 3-dimethyl-1-chlorobutane; (3) oxidating 3, 3-dimethyl-1-chlorobutane to obtain 3, 3-dimethyl butyraldehyde, and purifying; and (4) carrying out a reaction of 3, 3-dimethyl butyraldehyde with aspartame to form imine, and catalytic-hydrogenating to obtain Neotame. The invention has the advantages of simple process, easy operation, low cost, and high purity of the product.

Description

technical field [0001] The invention relates to a synthesis method of a food additive neotame. Background technique [0002] Neotame (NTM) is a new type of strong sweetener, the second generation of aspartame (APM), its chemical name is N-[N-(3,3-dimethylbutyl)]- L-a-Asparagine-L-phenylalanine-1-methyl ester. [0003] The structural formula is: [0004] [0005] The sweetness of neotame is 8000 times that of sucrose, the sweetness is pure, and the sweetness characteristics are almost the same as sucrose; the stability is good, overcoming the disadvantage of poor stability of aspartame; no caries, and has a positive effect on tooth protection; Adding it to food can maintain or even improve good flavors such as sweetness, saltiness, and sourness, while reducing or covering up bad tastes such as bitterness, astringency, and some irritating odors; the energy value is almost zero, and will not Causes fluctuations in blood sugar in the body. It has been approved as a food a...

Claims

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Application Information

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IPC IPC(8): C07K5/06A23L1/236A23L27/30
Inventor 晏日安
Owner JINAN UNIVERSITY
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