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Drop pills of sweet wormwood oil for relieving cough and resolving phlegm and preparation process thereof

A technology for oil drop pills and artemisia annua oil, applied in the field of artemisia annua oil drop pills, can solve the problems such as the roundness rate, the dissolution time limit and the hardness index of the drop pills, which are difficult to meet the preparation requirements and the content is reduced.

Inactive Publication Date: 2007-05-30
王丽娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the active ingredients of Artemisia annua oil drop pills are volatile ingredients, the roundness rate, dissolution time limit and hardness index of the drop pills are not easy to meet the requirements of the preparation when preparing the drop pills, and the preparations are stored due to the volatilization of the active ingredients. Its content has been greatly reduced, which has become a major problem in the preparation of Artemisia annua oil dripping pills

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (a) According to the 1:7 ratio of medicinal ingredients and matrix, weigh 30g of Artemisia annua Oil, 10g of Vitex Vitex Oil, 5g of Licorice Extract and 315g of Polyethylene Glycol (4000). (4000) placed in a heating container and heated to a molten state; adding artemisia annua oil, vitex oil and licorice liquid extract in stages, and stirring evenly;

[0017] (b) Adopt a self-made dripping pill machine, adjust the temperature control system of the dripping pill machine, keep the temperature of the dripper of the dropping pill machine at (75-85) °C, and make the temperature gradient of the condensing agent be (30-20) °C →(5~-5)℃;

[0018] (c) When the temperature of the dripper and the condensing agent of the dripping pill machine have been stabilized in the required state of the second step, pass the melted material through the dripper of the dripping pill machine (dropper diameter: 2mm / 4.2mm) to Drop into the methyl silicone oil at an appropriate speed;

[0019] (d)...

Embodiment 2

[0022] (a) According to the 1:5 ratio of medicinal ingredients and matrix, weigh 30g of artemisia annua oil, 20g of mugwort oil, 230g of polyethylene glycol (4000), 13g of polyethylene glycol (20000), and 7g of sodium stearate , first place polyethylene glycol (4000), polyethylene glycol (20000) and sodium stearate in a heating container, and heat to a molten state; add artemisia annua oil and mugwort oil in stages, and stir evenly;

[0023] (b) Adopt a self-made dripping pill machine, adjust the temperature control system of the dripping pill machine, keep the temperature of the dripper of the dropping pill machine at (75-85) °C, and make the temperature gradient of the condensing agent be (30-20) °C →(5~-5)℃;

[0024] (c) When the temperature of the dropper of the dropping pill machine and the condensing agent have been stabilized in the state required in the second step, pass the melted material through the dropper of the dropping pill machine (dropper caliber: 2mm / 4.2mm) t...

Embodiment 3

[0028] (a) According to the 1:3 ratio of medicinal ingredients and matrix, weigh 30 g of artemisia annua oil, 0.5 g of Tween-80, 40 g of polyethylene glycol (6000) and 35 g of polyethylene glycol (4000), first Put Tween-80, polyethylene glycol (6000) and polyethylene glycol (4000) in a heating container, heat to a molten state; add Artemisia annua oil and stir well;

[0029] (b) Adopt a self-made dropping pill machine, adjust the temperature control system of the dropping pill machine, keep the temperature of the dripper of the dropping pill machine at (75-85) °C, and make the temperature gradient of the condensing agent be (30-20) °C →(5~-5)℃;

[0030] (c) When the temperature of the dripper and the condensing agent of the dripping machine have been stabilized in the state required in the second step, pass the melted material through the dripper of the dripping machine (the inner diameter of the dropper mouth: 2 ~ 4mm), and Drop into the methyl silicone oil at an appropriate...

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Abstract

The invention discloses a medicinal composition having functions of resolving phlegm, relieving cough, and lowering the adverse rise of energy, thus being mainly used for treating chronic bronchitis. The composition is prepared into oral administration dripping pills comprising sweet wormwood oil as the effective constituent and medicinal carrying agent as the base material.

Description

technical field [0001] The invention relates to an annua oil drop pill with functions of eliminating phlegm, relieving cough and relieving asthma, and also relates to a preparation method of the dropping pill. Background technique [0002] Artemisia annua oil capsules are recorded in the National Standards Compilation of Chinese Patent Medicines and National Standard Pulmonary System (II). A commonly used oral pharmaceutical formulation for the treatment of chronic bronchitis. Gelatin is mostly used as the capsule body material for the preparation of capsules. Due to the characteristics of gelatin and the preparation technology, the outer skin of the capsule is prone to aging during the storage of capsules, which will produce certain insoluble substances in the human body. Residues in the human body will have a certain impact on the health of the human body. Therefore, many medical workers at home and abroad are constantly conducting in-depth research in order to seek to im...

Claims

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Application Information

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IPC IPC(8): A61K36/282A61K36/85A61K36/71A61K36/59A61K36/534A61K36/45A61K36/484A61P11/06A61P11/10A61P11/14A61K31/045
Inventor 周玉新
Owner 王丽娟
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