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Method for preparing colon targeted pill of polymyxin B sulfate used for poultry and livestock

A polymyxin sulfate, colon targeting technology, applied in the directions of pill delivery, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problem of not yet retrieved invention patents, etc., and achieve the effect of good therapeutic effect

Inactive Publication Date: 2007-05-30
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] No patents have been retrieved for the invention of this drug in the field of veterinary drug targeted preparations

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the preparation method of polymyxin B sulfate colon targeting pill

[0041] 1. Drugs, excipients and reagents

[0042] Polymyxin B sulfate raw material, Eudragit S100, triethyl citrate, blank pellets 40 mesh, HPMC 15MPa.S, 10MPa.S, 5MPa.S, 95% ethanol.

[0043] 2. Instruments and equipment

[0044] EPL-1 fluidized bed, 78HW-1 magnetic stirrer, J-11 stirrer

[0045] 3. Preparation method

[0046] 1. Place 900 g of blank pellets in a fluidized bed, and coat the drug layer, retardation layer, time lag layer and pH-sensitive film in sequence according to the following methods and processes.

[0047] (1) Coating of the main drug

[0048]Preparation of coating liquid: dissolve 100 g of polymyxin B sulfate in 1000 ml of 50% ethanol.

[0049] Coating conditions:

[0050] Material temperature: 40°C Air outlet temperature: 40°C Liquid supply hose inner diameter: 2mm

[0051] Air inlet temperature: 48°C Liquid supply speed: 20r / min Spray gun diameter: 1.2mm

...

Embodiment 2

[0073] Embodiment 2: The medicine of the present invention is used as a polypeptide antibiotic, which mainly has a strong antibacterial effect on Gram-negative bacteria, especially on Pseudomonas aeruginosa, and less drug resistance. It is used to control and treat various local or systemic infections in livestock and poultry caused by Gram-negative bacteria, especially Pseudomonas aeruginosa. The method of administration is mixing, 28mg-34mg / kg body weight of calves, piglets, and poultry; the dose is halved when it is used in combination with neomycin, bacitracin and other drugs. The medicine can achieve more than 88% cure rate for the disease.

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PUM

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Abstract

The invention discloses a fluorobenzenenicore colon targeting pill of flock, which comprises the following parts: fluorobenzenenicore as drug layer, 8% ethol as retarding layer, 2% HPMC as time lag layer and 15% S100 as sensitive film.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to a polymyxin B sulfate colon-targeted pill for treating diseases caused by bacterial infection in livestock and poultry. Background technique [0002] With the continuous improvement of the scale and intensification of livestock and poultry breeding, various problems in breeding also follow. Some diseases caused by bacteria and mycoplasma often occur in livestock and poultry. For the above-mentioned situation, the current method of treating this type of disease is mainly to control this type of disease with antibiotics. In terms of human medicine, there is a colon-targeted drug delivery system (OCDDS), which is a targeted preparation that releases drugs in the colon. Oral colon-targeted drug delivery system is a research hotspot recently. It is a new preparation for localized drug release in the colon through oral administration to achieve local or systemic treatment. ...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61K9/20A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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