35 results about "Polymyxin B Sulfate" patented technology

An ointment composition for treating decubitus ulcers and methods for its making and its use. The composition includes a skin protestant ointment, a rash cream, an antibiotic ointment, virgin olive oil, and boric acid powder. The skin protestant ointment includes active ingredients petroleum 53.4%, lanolin 15.5%, and inactive ingredients cod liver oil containing vitamin A & vitamin D, a fragrance, light mineral oil, microcrystalline wax, and paraffin. The rash cream includes active ingredients dimethicone 1% and zinc oxide 10%, and inactive ingredients aloe barbadensis extract, benzyl alcohol, coconut oil, cod liver oil containing vitamin A & vitamin D, a fragrance, glycerol oleate, light mineral oil, ozokerite, paraffin, propylene glycol, sorbitol, synthetic beeswax, and water. The antibiotic ointment includes active ingredients polymyxin B sulfate 5,000 units, bacitracin zinc 400 units, and neomycin base (as sulfate) 3.5 mg., and an inactive ingredient white petroleum.

The invention provides a culture medium for fermenting polymyxin B sulfate. Each 100ml of the culture medium is prepared from the following components: 6g to 12g of flour, 0.03g to 0.06g of high-temperature amylase, 0.4g to 2g of cottonseed meal, 0.3g to 1g of corn pulp, 0.01g to 0.05g of dipotassium phosphate, 0.2g to 0.6g of ammonium sulfate, 0.2g to 0.6g of calcium carbonate, 0.02ml to 0.08ml of a de-foaming agent and the balance of water. A method for fermenting and producing the polymyxin B sulfate comprises the following the steps: inoculating the culture medium with strain seed liquid for producing the polymyxin B sulfate; fermenting and culturing fermentation liquid at 26 DEG C to 32 DEG C, wherein the pH (Potential of Hydrogen) value is 6.7 to 7.4 at the beginning of fermenting; controlling the pH value of the fermentation liquid to be natural during a fermentation process, wherein the dissolved oxygen volume concentration of the fermentation liquid is 10 percent to 30 percent. All the components of the culture medium are cooperatively matched and the content of impurities B2P is controlled to be lower than 1.5 percent.

This invention relates to a moisturizing skin ointment composition consisting of polymyxin B Sulfate, bacitracin zinc, neomycin (the combination of which totals 1 ounce), hydrocortisone acetate (1 ounce) and white petrolatum (13 ounces). When combined and water evaporated, an external ointment that penetrates the skin and alleviates dry skin conditions, itching and minor scrapes and scratches is created. The properties of the antibiotic products help to promote healing of minor scrapes and scratches as well as preventing the spread of dry skin conditions. The properties of the hydrocortisone aids in the alleviation of itching associated with dry skin. Because this ointment penetrates the dermis almost immediately, the moisturizing properties of petrolatum allows the full benefit of the antibiotic products and hydrocortison to remain on / in the skin through several washings thereby alleviating the need to reapply several times a day.

The antimicrobial hydrogel wound dressing is a swellable polymer gel made from about 7-9% (wt / vol) polyvinyl alcohol (PVA), preferably 8.9%, about 0.1% (wt / vol) polyvinyl pyrrolidone (PVP), and about 1-2% (wt / vol) agar, preferably 1%, the balance (about 90%) being distilled water, the foregoing contents being crosslinked by gamma radiation at a dose of about 30 kGy. Prior to crosslinking by gamma radiation, an effective amount of a pair of antibiotics is added to the gel at room temperature. The antibiotics include about 10,000 IU of polymyxin B sulfate, and about 5 mg neomycin per gram of gel. The polymyxin provides effective protection against various forms of gram negative microorganisms, and the neomycin is a broad spectrum antibiotic that provides protection against various forms of gram positive microorganisms. The hydrogel has sufficient mechanical strength for use as a wound dressing, and is capable of absorbing water up to 900% of its volume.

Wound Dressings for improved treatment of wounds on a patient. A wound dressing having a bandage and a healing composition. The healing composition includes from about 5 mg to about 40 mg lidocaine hydrochloride per gram of the healing composition, from about 250 units to about 2000 units polymyxin B sulfate per gram of the healing composition, and from about 10 units to about 100 units bacitracin zinc per gram of the healing composition. Article of manufacture having a packaging material and the healing composition. The packaging material includes a label indicating composition is useful for treating a patient having a skin wound and that local administration of the composition enhances healing of a skin wound.

The invention discloses an external gel for skin wounds. The external gel is prepared from the following raw materials in parts by weight: 1-3 parts of an active component A, 4-6 parts of an active component B, 10-14 parts of a Calendula arvensis extract, 16-20 parts of a Centella asiatica extract, and 60-80 parts of an auxiliary material, wherein the active component A is at least two of polymyxin B sulfate, neomycin sulfate and bacitracin, the active component B is at least one of lidocaine hydrochloride, pramoxine hydrochloride, procaine hydrochloride and menthol, and the auxiliary materialcomprises the following raw materials in parts by weight: 0.5-3 parts of carbomer, 40-75 parts of an organic solvent, and 20-50 parts of purified water. The external gel provided by the invention hasprevention and treatment effects on the bacterial infection of skin wound parts, has analgesic and hemostatic effects on skin wounds, can promote the formation of capillaries and collagenous fibers of wound surfaces, reduces the healing days of wound surfaces, and can be used for the healing of skin wounds such as burn wounds, incised wounds and scald wounds, the healed skin is smooth and free ofscars, and thereby the healing effect is good.

The invention discloses a method for extracting polymyxin B from a fermentation broth of the polymyxin B. The method for extracting the polymyxin B from the fermentation broth of the polymyxin B comprises the following steps: a, conducting solid-liquid separation on the fermentation broth of the polymyxin B and obtaining a filtrate; b, extracting the filtrate with a polar organic solvent, and extracting an extract liquor reversely with water when the extract liquor is at the potential hydrogen (pH) value of 1.0-2.0; c, adding the reversal extract liquor which is obtained from the step b into inorganic salt, wherein the volume of the reversed extract liquor of the inorganic salt is 3-8% (w / v), and adjusting the pH value to be 9.0-10.0 so that the polymyxin B is obtained after precipitation and sediment. Preferably, the method for extracting the polymyxin B from the fermentation broth further comprises a step of d: reacting the polymyxin B and sulfuric acid to form salt, and dissolving and precipitating, thereby obtaining the polymyxin B sulfate. The polymyxin B or the sulfate prepared by means of the method is higher in yield and purity, the purity of a product is above 85%, the tilter is above 8100IU / g, and the yield is above 60%. The method for extracting polymyxin B from the fermentation broth has the advantages of being easy and convenient to operate, short in time consuming, low in requirement of equipment, and capable of recycling the organic solvent and being used for large-scale industrial production.

The invention provides a culture medium for fermenting polymyxin B sulfate. Each 100ml of the culture medium is prepared from the following components: 6g to 12g of flour, 0.03g to 0.06g of high-temperature amylase, 0.4g to 2g of cottonseed meal, 0.3g to 1g of corn pulp, 0.01g to 0.05g of dipotassium phosphate, 0.2g to 0.6g of ammonium sulfate, 0.2g to 0.6g of calcium carbonate, 0.02ml to 0.08ml of a de-foaming agent and the balance of water. A method for fermenting and producing the polymyxin B sulfate comprises the following the steps: inoculating the culture medium with strain seed liquid for producing the polymyxin B sulfate; fermenting and culturing fermentation liquid at 26 DEG C to 32 DEG C, wherein the pH (Potential of Hydrogen) value is 6.7 to 7.4 at the beginning of fermenting; controlling the pH value of the fermentation liquid to be natural during a fermentation process, wherein the dissolved oxygen volume concentration of the fermentation liquid is 10 percent to 30 percent. All the components of the culture medium are cooperatively matched and the content of impurities B2P is controlled to be lower than 1.5 percent.

The invention discloses a drug for treating fungal infection of a pet, and a preparation method thereof. The drug comprises the following components in percentage by mass: 5.86-13.4% of active ingredients, 10-24% of mineral oil, 12-30% of propylene glycol, 10-24% of glycerinum, 3-12% of DC-345, 0.5-2% of sodium chloride, 0.5-6% of EM-90, 2-10% of R9331, and the balance of water, wherein the active ingredients comprise 1.2-2.0% of nystatin, 0.4-0.8% of neomycin sulfate, 0.2-0.5% of polymyxin B sulfate, 0.06-0.1% of triamcinolone acetonide, and 4%-10% of lidocaine sulfate. The invention further provides the preparation method of the preparation. The drug is prepared by matching the components through a specific proportion and mainly aims at common skin diseases caused by various fungal infections of pet dogs and pet cats and symptoms of wound infection fester or long-time non-cicatrization caused by trauma.

The invention provides a compound oxytetracycline oculentum for pets, the compound oxytetracycline oculentum comprises, by mass, 0.5-5% of an active component and 95-99.5% of an oculentum matrix, the active component comprises oxytetracycline hydrochloride and polymyxin B sulfate, and the oculentum matrix comprises albolene and liquid paraffin. The raw materials and the auxiliary materials are medicinal, the quality is easy to control, and the preparation is convenient; the active ingredients are anti-infection western medicine ingredients which are clear and are safer than some complex traditional Chinese medicine ingredients; and the compound oxytetracycline oculentum for pets has an obvious effect on treating eye infection of pets.

The invention discloses an analytical detection method of polymyxin sulfate B, comprising the steps of analytically detecting polymyxin sulfate B via high-performance liquid chromatography in combination with an evaporative light scatterer. The method allows four components in polymyxin sulfate B to be fully separated, has high specificity, is simple to perform, is free of disturbance by other organic impurities, is approximately effective to HPLC (high-performance liquid chromatography) of EP 9.0 bulk pharmaceutical chemicals in terms of high sensitivity, good simplicity and high speed, and allows the contents of components in a polymyxin sulfate B preparation to be measured more accurately.

The invention provides a composite hydrogel wound dressing and a preparation method thereof, which is based on aminated collagen and oxidized sodium alginate, and is loaded with two polypeptides of polymyxin B sulfate and bacitracin Antibiotics, AC / OSA‑PB composite hydrogel dressings are prepared by Schiff base reaction, the preparation method of the present invention is simple to operate, and has low requirements on reaction conditions, and can be gelled in a short time, which is beneficial to large-scale production, and the obtained The wound dressing not only has a good bactericidal effect, but also can maximize the HSF cell migration rate and HSF cell proliferation rate, has an excellent ability to promote wound healing, and also has mechanical properties and mechanical properties suitable for skin wounds.

The invention discloses an impurity D17 of polymyxin B sulfate and a separation and preparation method thereof. The growth of the impurity under different conditions of temperature and pH is investigated. The preparation method provides a guarantee to control the content of the impurity, optimize the industrial production of the polymyxin B sulfate and improve the quality of a medicine.