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Pyridyl quaternary ammonium salt antiseptic and its prepn process

A technology of pyridinium quaternary ammonium salt and antibacterial agent, which is applied in the field of pyridinium quaternary ammonium salt antibacterial agent and its preparation, can solve the problems that the structure and antibacterial property of quaternary ammonium salt have not been studied in detail, achieve good bactericidal effect, simple preparation method, The effect of high affinity

Inactive Publication Date: 2007-06-06
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present people just select some existing quaternary ammonium antibacterial agents, such as dodecyl pyridinium chloride, dodecyl dimethyl benzyl ammonium chloride and dodecyl trimethyl ammonium bromide etc. , the adsorption on wool, antibacterial properties and durability were studied, but the relationship between the structure of quaternary ammonium salts and antibacterial properties was not specifically studied

Method used

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  • Pyridyl quaternary ammonium salt antiseptic and its prepn process
  • Pyridyl quaternary ammonium salt antiseptic and its prepn process

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Put a mixture of 10g of benzoyl chloride and 50ml of acetone into a 250ml three-neck flask, cool it in ice water to 0-5°C, dissolve 5g of 4-aminopyridine in an appropriate amount of acetone, and stir it within 30min Continuously add to the benzoyl chloride solution, keep the temperature and continue the reaction for 1 hour, after completion, remove the acetone solution to obtain white crystals of benzamidopyridine, which are recrystallized in water. Dry in a vacuum oven. The yield is about 93%.

[0020] Dissolve 7.8g of benzamidopyridine and 3.8g of dodecyl bromide in 100ml of DMSO, put them in a 250ml flask, heat the mixture in an oil bath at 100°C for about 4 hours, remove DMSO in a vacuum evaporator, The reaction product was washed with ether, and recrystallized in an ether-ethanol mixed solvent to obtain light yellow solid particles, which were then vacuum-dried in a vacuum dryer for more than 24 hours.

[0021] Gained pyridine quaternary ammonium antibacterial ag...

Embodiment 2

[0024] Put a mixture of 7.6g of 1-naphthoyl chloride and 80ml of acetone into a 250ml three-neck flask, cool it in ice water to 0-5°C, dissolve 3.8g of 4-aminopyridine in an appropriate amount of acetone, and stir It was continuously added to the 1-naphthoyl chloride solution within 30 minutes, and the temperature was maintained to continue the reaction for 1 hour. After completion, the acetone solution was removed to obtain white crystals of 1-naphthoylaminopyridine. Dry in a vacuum oven. The yield is about 92%.

[0025] Dissolve 6.4g of 1-naphthoylaminopyridine and 7.0g of dodecyl bromide in 100ml of DMSO, put them in a 250ml flask, heat the mixture in an oil bath at 100°C for about 4 hours, and remove it in a vacuum evaporator Wash the reaction product with DMSO and diethyl ether, and recrystallize in a diethyl ether-ethanol mixed solvent to obtain a light yellow solid particle, which is then vacuum-dried in a vacuum dryer for more than 24 hours.

[0026] Gained pyridine ...

Embodiment 3

[0029] Put a mixture of 7.6g of 2-naphthoyl chloride and 80ml of acetone into a 250ml three-neck flask, cool it in ice water to 0-5°C, dissolve 3.8g of 4-aminopyridine in an appropriate amount of acetone, and stir It was continuously added to the 1-naphthoyl chloride solution within 30 minutes, and the temperature was maintained to continue the reaction for 1 hour. After completion, the acetone solution was removed to obtain 1-naphthoylaminopyridine as white crystals. Dry in a vacuum oven. The yield is about 94%.

[0030] Dissolve 6.4g of 1-naphthoylaminopyridine and 7.0g of dodecyl bromide in 100ml of DMSO, put them in a 250ml flask, heat the mixture in an oil bath at 100°C for about 4 hours, and remove it in a vacuum evaporator The reaction product was washed with DMSO and diethyl ether, and recrystallized in a diethyl ether-ethanol mixed solvent to obtain light yellow solid particles, which were then vacuum-dried in a vacuum dryer for more than 24 hours.

[0031] Gained p...

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Abstract

The present invention is pyridyl quaternary ammonium salt antiseptic and its preparation process. The pyridyl quaternary ammonium salt antiseptic is 4-phenylamido-1-polyalkyl pyridyl ammonium halide or 4-(1 or 2-naphthyl amido)-1-polyalkyl pyridyl ammonium halide. It is used in antiseptic finishing of protein fiber, acrylon and other fiber. The preparation process includes the following steps: 1. setting benzoyl chloride or naphtholyl chloride inside acetone as organic solvent, cooling to 1-5 deg.c, adding 4-aminopyridine to react for 2 hr to obtain benzoyl aminopyridine or naphtholyl aminopyridine, filtering and stoving; and 2. dissolving the product of the last step in N, N-dimethyl sulphoxide solvent, adding alkyl halide, heating to 100-120 deg.c to react for 4-5 hr to obtain 4-phenylamido-1-polyalkyl pyridyl ammonium halide or 4-(1 or 2-naphthyl amido)-1-polyalkyl pyridyl ammonium halide, and vacuum drying.

Description

technical field [0001] The invention belongs to the field of textiles, in particular to a class of pyridinium quaternary ammonium antibacterial agents and a preparation method thereof. Background technique [0002] At present, with the widespread spread of harmful germs, people have paid great attention to textiles with antibacterial functions. Textiles with antibacterial functions are becoming more and more protective against cross-infection in public places such as hospitals, nursing homes, schools and hotels. more important. There are two main purposes of textile antibacterial finishing, one is to prevent the wearer of textiles from being attacked by pathogens, and the other is to prevent damage to textiles by certain microorganisms and molds. An ideal antibacterial finishing agent should have the characteristics of fast sterilizing speed, good durability, safety to human body and environment, easy to use, little impact on fabric performance and low cost. Textiles after...

Claims

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Application Information

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IPC IPC(8): A01N43/40A01P3/00D06M13/355D06M101/12D06M101/34D06M101/32D06M101/28
Inventor 赵涛王革辉孙刚
Owner DONGHUA UNIV
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