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Dual-scale micro-structure artificial bone scaffold and preparation method thereof

A technology of microstructure and artificial bone, applied in scaffolds, bone implants, medical science, etc., can solve problems such as poor nutrient transport function, high porosity, etc., to ensure integrity, ensure continuous supply, and evenly distribute the flow field Effect

Inactive Publication Date: 2007-07-11
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing microstructures of artificial bone scaffolds are mainly porous and tubular. The nutrient transport function of the porous pores is relatively poor, and it is difficult to form a high porosity during the preparation of the tubular pores.

Method used

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  • Dual-scale micro-structure artificial bone scaffold and preparation method thereof
  • Dual-scale micro-structure artificial bone scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment one: the concrete steps of the present invention are as follows:

[0027] 1) Obtain the shape data of the scaffold through CT scanning or directly design the shape of the scaffold through CAD software, design the internal microstructure of the scaffold using CAD software, and then combine the shape of the scaffold with the internal microstructure data to form a CAD with the negative shape of the macroscale pipeline artificial bone scaffold Model;

[0028] 2) Convert the CAD model data containing the negative shape of the macroscale pipeline artificial bone scaffold into an STL file format, and use the rapid prototyping layering software Rpdata for layered slice processing to generate the default format file of the light-curing rapid prototyping equipment, and the format file is input to In the light-curing rapid prototyping equipment, the resin mold containing the macro-scale pipe bracket is prepared by the light-curing rapid prototyping equipment;

[0029] ...

Embodiment 2

[0031] Embodiment two: the concrete steps of the present invention are as follows:

[0032] 1) Obtain the shape data of the scaffold through CT scanning or directly design the shape of the scaffold through CAD software, use CAD software to design the internal microstructure of the scaffold, and then combine the scaffold shape and internal microstructure data to form a CAD with the negative shape of the macroscale pipeline artificial bone scaffold Model;

[0033] 2) Convert the CAD model data containing the negative shape of the macro-scale pipeline artificial bone scaffold into an STL file format, and use the rapid prototyping layering software Rpdata for layered slice processing to generate the default format file of the light-curing rapid prototyping equipment, and the format file is input to In the light-curing rapid prototyping equipment, the resin mold containing the macro-scale pipe bracket is prepared by the light-curing rapid prototyping equipment;

[0034]3) Prepare ...

Embodiment 3

[0036] Embodiment three: the concrete steps of the present invention are as follows:

[0037] 1) Obtain the shape data of the scaffold through CT scanning or directly design the shape of the scaffold through CAD software, design the internal microstructure of the scaffold using CAD software, and then combine the shape of the scaffold with the internal microstructure data to form a CAD with the negative shape of the macroscale pipeline artificial bone scaffold Model;

[0038] 2) Convert the CAD model data containing the negative shape of the macroscale pipeline artificial bone scaffold into an STL file format, and use the rapid prototyping layering software Rpdata for layered slice processing to generate the default format file of the light-curing rapid prototyping equipment, and the format file is input to In the light-curing rapid prototyping equipment, the resin mold containing the macro-scale pipe bracket is prepared by the light-curing rapid prototyping equipment;

[0039...

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Abstract

The invention relates to a dual-size micro bone support and relative production, wherein said support comprises micro ball connecting hole and macro tube; the micro tube is formed by connected ball holes; the macro tube is formed by connected straight tubes; the ball hole is through to the tube; the ball holes are randomly arranged; the tube structure can be controlled. And production comprises that: first using CAD and light solidifying shaping technique to design and control the tube structure; preparing the resin mould of bone structure; filling mineral wax balls into mould; filling biological slurry; when it is solidified and dried, thermally decomposing the resin mould and mineral wax, to obtain the bone support.

Description

technical field [0001] The invention relates to an artificial bone support used in the medical industry for bone repair, in particular to a preparation method of a double-scale microstructure artificial bone support. Background technique [0002] For large bone defects, when biomaterials are directly used for filling and repairing, it is difficult for bioactive substances (growth factors, bone cells) and tissue fluid to penetrate into the large material, and the speed of blood vessel growth is also quite slow. Apply directly. Medical anatomical research on natural bone shows that there is a complex microstructure system inside the bone. This system ensures the blood circulation in the bone and the metabolism and exchange of nutrients, maintains the activity of the bone, and supports the growth of the bone. growth and regeneration. For artificial bone scaffolds used to repair large bone defects, the porous structure system is a necessary condition for new bone ingrowth and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61F2/82A61F2/00A61B17/56A61L27/00
Inventor 李涤尘徐尚龙王璐
Owner XI AN JIAOTONG UNIV
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