Process for preparing rosmarinic acid

A technology of rosmarinic acid and ascorbic acid, applied in the separation/purification of carboxylic acid esters, organic chemistry, etc., can solve problems such as long time consumption, unsuitable for industrial production, and residual organic solvents, so as to avoid degradation, reduce pressure, The effect of maintaining stability

Inactive Publication Date: 2007-07-11
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This process takes a long time and is easy to cause organic solvent residues, so it is not suitable for industrial production

Method used

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  • Process for preparing rosmarinic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Embodiment 1: the preparation of rosmarinic acid

[0045] Solvent extraction (dipping method): take Danshen and grind it through a No. 3 sieve, weigh 50Kg, add 50% ethanol according to 20 times its weight, soak at room temperature for 4 hours and stir properly, separate the extract, and the residue is 10 times the weight of the original medicinal material. Add 50% ethanol twice, soak at room temperature for 6 hours and stir properly, and separate the extract. Combine the two extracts, and remove solid impurities therein by filtration or centrifugation. Antioxidant sodium bisulfite is added into the filtrate, and the consumption of sodium bisulfite is 0.005% of the volume of the extract. After standing for 6 hours, the solution became turbid and precipitates gradually appeared, which were removed by filtration.

[0046] The above-mentioned filtrate is adjusted to about 20% alcohol concentration with water, and is added to a polyamide column, and the ratio of the sample...

Embodiment 2

[0048] Embodiment 2: the preparation of rosmarinic acid

[0049] It is basically the same as in Example 1, except that the medicinal material is perilla. Finally, 136 g of products with a rosmarinic acid content of 92.6% were obtained.

Embodiment 3

[0050] Embodiment 3: the preparation of rosmarinic acid

[0051] It is basically the same as in Example 1, except that the medicinal material is selected from Cinnamomum capitulata. Finally, 256 g of products with a rosmarinic acid content of 95.8% were obtained.

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Abstract

The invention discloses a making method of rosmarinic acid, which comprises the following steps: immersing the medicinal material with rosmarinic acid in the fitful quantity of solvent; permeating; extracting through ultrasound; adding anti-oxidant in the extract; adjusting pH value to acid; stewing; filtering; chromatographing the filtrate in the polyamide resin or ion exchange resin or large-hole resin column; fitting for large scale of industrial manufacturing.

Description

technical field [0001] The invention relates to a preparation method of rosmarinic acid. Background technique [0002] Rosmarinic acid (RosA for short), the chemical name is R(+)2-((3-(3,4-dihydroxyphenyl-(-oxygen-2-propenyl)oxy)3,4 -dihydroxyphenylpropionic acid) is a multifunctional phenolic acid compound, which was first discovered by Ellis from the medicinal material rosemary, so it was named rosmarinic acid. Rosmarinic acid is widely found in rosemary, Among the labiatae medicinal materials such as perilla leaf, salvia miltiorrhiza, kidney tea, etc. Rosmarinic acid, as an antioxidant, has a strong activity of scavenging free radicals in the body, and its antioxidant activity is stronger than that of caffeic acid, chlorogenic acid, folic acid, etc. It can also inhibit the oxidation of low-density lipoprotein regulated by endothelial cells. Rosmarinic acid also has antiviral activity. Arda et al. found that the alcoholic water extract of bean sprouts has anti-HIV (human ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/48C07C69/73
Inventor 曲桂武岳喜典
Owner SHANDONG LUYE PHARMA CO LTD
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