Array micro-fluidic chip device for use in drug metabolism screening
A technology of microfluidic chips and arrays, which is applied in the direction of testing pharmaceutical preparations, biological tests, and material inspection products. It can solve the problems of large consumption of reagents and samples, difficult separation of products, and short service life. It achieves convenient operation and easy operation. Separation, device making simple effect
Inactive Publication Date: 2011-06-01
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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[0003] At present, the traditional in vitro drug metabolism screening methods mainly include in vitro incubation of liver microsomes, in vitro incubation of hepatocytes, isolated liver perfusion, and liver tissue slices. These methods have the disadvantages of slow analysis speed, large consumption of reagents and samples, and Disadvantages such as short service life or difficult separation of hatched products
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[0017] refer to Figure 4 , the device of the present invention includes a sampling interface for introducing samples and a microfluidic chip 1 for reacting the samples. The sample injection interface includes an upper cover 6 and a lower cover 7, which can be made of plexiglass, and two screw holes are set at the corresponding positions on both sides of the upper and lower cover 6, 7 so that the upper and lower can be adjusted by two screws 9. Cover sheets 6, 7 are relatively fixed. In addition, a plurality of through holes are provided on the upper cover sheet 6, and its position and number correspond to the chip liquid storage tank 3 to be described in detail below, and the number of through holes is between Figure 4 Four are shown in , but there may be more, such as five, or less, such as two. In addition, in these through holes, there are respectively fixed sampling tubes 10 made of stainless steel or other suitable materials, the inner and outer diameters of which are...
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The matrix microflow control chip for medicine metabolism screening comprises sample incoming interface and micro flow control chip, with the former made of top and bottom covers, with several sample intake ducts on the top cover, the integral micro flow control chip having several storage fluid entering pool at one side, several liquid output pool, with the micro flow control chip having severalmicro channel buried with active protein or contained with active protein, one end of the micro channel connected with one end of the liquid storage entering pool, the other end connected with one end of the liquid storage pool, the micro flow control chip fixed between the top and bottom covers of the sample intake interface and allowing the sample intake channel interior connected with the other end of the liquid entering pool. It is convenient, simple in operation, good in stability and high in analysis flux.
Description
technical field [0001] The invention relates to drug metabolism screening, in particular to a device for drug metabolism screening using an array microfluidic chip. Background technique [0002] Drug metabolism screening research is of great significance in new drug development and design, toxicology research and other aspects. In the early stage of new drug development, the study of drug metabolism screening can evaluate the drug metabolism characteristics of new drug candidates in order to find better candidates, which can provide structural modification design ideas for new drug development, and help to obtain safe and effective therapeutic drugs , to reduce the elimination rate of drug candidates. The study of drug metabolism involves the formation of metabolites, the determination of metabolic pathways, and the stability of metabolic processes. The in vitro metabolism research method can eliminate the interference of internal factors, directly observe the selective me...
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IPC IPC(8): G01N33/50G01N33/15
Inventor 吴会灵范国荣陈斌柴逸峰吴玉田杨芃原刘宝红
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY