Method for improving the half-life of soluble viral receptors on mucosal membranes

a technology of soluble viral receptors and mucosal membranes, which is applied in the direction of immunoglobulins against bacteria, pill delivery, antibody ingredients, etc., can solve the problem of geometric distortion of some viral particles and disrupt the growth of some viral particles
US20020086020A1Inactive Publication Date: 2002-07-04OSEL
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
OSEL
Publication Date
2002-07-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to methods of increasing the half-life of a viral-specific ligand on a mucosal membrane by modifying the viral-specific ligand to bind the bacteria colonized on the mucosal membrane. The invention also provides a chimeric molecule comprising a viral-specific ligand and a bacterial-specific ligand.
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Description

CROSS-REFERENCES TO RELATED APPLICATIONS

[0001] This application claims the priority of U.S. Provisional Application No. 60 / 129,722, filed on Apr. 16, 1999, the disclosure of which is hereby incorporated by reference.STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT

[0002] Not applicable.

[0003] The use of soluble viral receptors to prevent viral infection is being actively pursued. Amongst these efforts, intranasal administration of soluble ICAM-1 is being tested to prevent rhinovirus (cold) infection (Boehringer Ingelheim and Bayer). Soluble viral receptors are designed to work by engaging all host binding sites of a virus, thereby leaving none for the virus to attach to its target cell. However, a single viral particle has numerous binding sites for the host cell on its surface, e.g. rhinovirus has 60. Soluble viral receptors must simultaneously coat all binding sites on the virus to render it non-infectious. This requires an extremely high...

Claims

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