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Mask for relieving respiratory tract infectious diseases and using method thereof

A respiratory and mask technology, applied in botany equipment and methods, biochemical equipment and methods, applications, etc., can solve the problems of ineffective vaccines and easy mutations, so as to prevent other respiratory infectious diseases and reduce accidents Effect

Pending Publication Date: 2021-07-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The new coronavirus is an RNA virus, it is easy to mutate, and the vaccine produced is not 100% effective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Immerse a commercially available ordinary mask of two-layer gauze or three-layer gauze directly into 1% sodium chloroacetate solution, add 2ml of dimethyl sulfoxide, add 1g of sodium hydroxide, and react overnight at room temperature, take out the second-layer gauze or three-layer mask The ordinary mask with one layer of gauze is rinsed with water to terminate the reaction.

[0020] Then add 10 mg carbodiimide solution, react at room temperature for 20 min, take out the gauze and rinse off excess cross-linking reagent, then add 1% trypsin solution and react at room temperature for 2 hours. Immobilized trypsin was prepared by washing and drying.

[0021] During use, the trypsin-treated solid-phase enzyme mask (in the outer layer) is used in combination with the medical surgical mask (inner layer), and is sprayed in combination with a spray bottle to maintain the suitable pH condition of the trypsin. Trypsin has a high activity under suitable pH conditions, and can degra...

Embodiment 2

[0023] Directly immerse a commercially available ordinary three-layer gauze mask into a 1% sodium chloroacetate solution, add 2ml of dimethyl sulfoxide, add 1g of sodium hydroxide, and keep at room temperature After overnight reaction, take out the ordinary mask with two layers of gauze or three layers of gauze and rinse it with water to terminate the reaction. Then add 10 mg carbodiimide solution, react at room temperature for 20 min, take out the gauze and rinse off excess cross-linking reagent, then add 1% trypsin solution and react at room temperature for 2 hours. Immobilized trypsin was prepared by washing and drying.

[0024] When in use, the trypsin-treated solid-phase enzyme gauze two or three layers are cut to an appropriate size and sewed on the outer layer of the medical surgical mask, so that the air enters the human body and first contacts with the trypsin on the gauze, and combines with the spray bottle The outer surface of the mask is sprayed to maintain a suit...

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Abstract

The invention relates to a mask for slowing down respiratory tract infectious diseases and a using method thereof, which are characterized in that hydroxyl on cellulose in gauze is introduced into carboxyl under an alkaline condition through a sodium chloroacetate method, and the introduced carboxyl is covalently coupled with amino in trypsin under the action of a water-soluble carbodiimide cross-linking agent to obtain the mask for slowing down the respiratory tract infectious diseases; the trypsin is covalently bound to the gauze to prepare the immobilized trypsin. According to the immobilized enzyme technology, protease is immobilized on gauze to form immobilized enzyme. A solution with the pH of 7.2-8.0 is filled in a small plastic spray bottle to spray steam mist to gauze, so the pancreatin is in a moist environment, the solid-phase pancreatin is in the optimum working pH range, and then the pancreatin is kept at a proper temperature through human respiration. The pancreatin destroys spike protein of protein on a surface of a new crown under proper conditions, so the pancreatin cannot be combined with a virus receptor in a human body, and the prevention and control effect of blocking the new crown virus is improved.

Description

technical field [0001] The invention relates to immunology, solid-phase enzyme technology in immunology technology, and the field of infectious diseases, serves for epidemic prevention work, and reduces the harm of infectious diseases by blocking the way of infection. [0002] Background of the invention [0003] The new coronavirus is an RNA virus, which is prone to mutations, and the vaccines produced are not 100% effective. Therefore, people can only stay at home, reduce going out, wear masks when going out, and maintain social distance and other measures to cut off the transmission of infectious diseases. [0004] Controlling the way of transmission is also an effective means. For this reason, this invention is launched, hoping that human society will be helpful in slowing down the prevention and control of infectious diseases [0005] So I can only think of other ways, noting that the new coronavirus is not resistant to high temperature, sensitive to alcohol, and sensit...

Claims

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Application Information

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IPC IPC(8): A41D13/11A41D31/30C12N11/12A01N63/50A01N25/10A01P1/00
CPCA01N25/10A41D13/1192A41D31/30A01N63/50C12N9/6427C12N11/12C12Y304/21004
Inventor 陈正贤刘小红吴铭华李怡卿韩兴民苏晨露肖宇郑联顺
Owner ZHEJIANG UNIV
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