Dermatological compositions and methods

Inactive Publication Date: 2005-03-17
UPSHER SMITH LABORATORIES INC
View PDF3 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

One aspect of the present invention combines dermatologically acceptable compositions (i.e., dermatological or dermatologic compositions) with one or more anesthetic and / or anti-inflammatory agents, preferably steroid anti-inflammatory agents. The compositions include at least one acid, amide, ester, or salt of an alpha-hydroxy acid, a beta-hydroxy acid, an alpha-keto acid, or combinations thereof (preferably at least one alpha-hydroxy acid, ester, amide, salt thereof, or combinations thereof). More preferably, the compositions include a combination of at least two salts, more preferably, at least one ammonium salt and at least one metal ion salt (preferably sodium or potassium salt) for enhanced penetration of the composition. Preferably, certain compositions include an anti-foaming agent.
These compositions can also optionally include topical vehicles such as non-ionic surfactants, thickeners, emollients, humectants, and preservatives to provide preparations, such as lotions, creams, etc., for dry skin having enhanced preventative and therapeutic attributes.
The present invention provides methods for treating a subject, preferably a mammal, and more preferably a human, such as reducing inflammation of the skin, reducing itching and / or pain of the skin, and treating skin disorders that include contacting the skin with compounds containing any of the compositions of the present invention.

Problems solved by technology

Such disorders can also include inflammation and be quite painful.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

examples

Objects and advantages of this invention are further illustrated by the following examples, but the particular materials and amounts thereof recited in these examples, as well as other conditions and details, should not be construed to unduly limit this invention.

examples 1-4

Preparation of Compositions Containing Anti-Inflammatory and / or Anesthetic Agents

Four preferred formulations, Formulations A-D, of a moisturizing cream are listed in Table 1. These compositions were made using the following procedure:

Ammonium Lactate Solution

A 50-70% ammonium lactate solution was purchased from Pfanstiehl Labs (Waukegan, Ill.) or PURAC America (Lincolnshire, Ill.).

Gum Phase Preparation

A portion of the purified water was measured into a jacketed kettle. The water was heated to about 80° C. to about 85° C. and mixed. With continued mixing, the magnesium aluminum silicate, NF (Vanderbilt, Norwalk Conn.) and methyl cellulose, USP, (Dow Chemical, Midland, Mich.) were added to the water. The Gum Phase was mixed for at least 45 minutes, until uniform, while maintaining a temperature of about 80° C. to about 85° C.

Water Phase Preparation

To a jacketed compounding kettle the following ingredients were added using a transfer pump: hot purified water, USP, and gly...

examples 4-6

Multiple Counter Ion Cream Formulations

Three preferred formulations, Formulations E-G, of moisturizing creams which, according to the present invention, incorporate ammonium and metal ion salts along with the acid / acid salt composition, are listed in Table 2. These compositions were made using the following procedure:

Hot Water / Active Phase

Water, methylparaben (Napp Technologies, Saddlebrook, Ill.), glycerin 99.5% (Dow Chemical, Midland, Mich.), and propylene glycol (Dow Chemical, Midland, Mich.) were combined and heated with mixing to about 70° C. to about 75° C. in a covered vessel. Active ingredients, such as pramoxine HCl (Abbott Labs, Waukegan, Ill.) or hydrocortisone acetate (Ceres Chemical, White Plains, N.Y.) were optionally added to the hot water phase to provide a hot water / active phase.

Oil Phase

Mineral oil (Penreco, Karns City, Pa.), stearic acid (Croda, Parsippany, N.J.), and self-emulsifying wax (POLAWAX, Croda, Parsippany, N.J.) was combined and heated with st...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Login to view more

Abstract

Dermatological compositions (methods of making and using) that include one or more anesthetic agents and / or one or more anti-inflammatory agents and / or a combination of ammonium, sodium, and potassium salts, preferably of an alpha-hydroxy acid.

Description

FIELD OF THE INVENTION The invention relates to topical compositions that provide dermatological benefit, such as for the treatment of inflammation, itching, pain relief, and / or other conditions associated with skin disorders. BACKGROUND OF THE INVENTION Severe dry skin disorders, known as ichthyosis, are often characterized by cracks, flakes, scales, redness, etc. Less severe, but more common, moderate to mild dry skin disorders are often characterized by less severe fissures, chaps, cracks, flakes, redness, etc. Such disorders can also include inflammation and be quite painful. Typically, such disorders are treated with topical oils, hydrating emollients, ointments, etc. The topical use of alpha-hydroxy and beta-hydroxy acids, alpha-ketoacids, and esters thereof, is well known in the art to be effective as a preventative as well as a therapeutic treatment of dry skin disorders. Treatment is generally effective at acid concentrations of about 1% to about 20% by weight. Skin irri...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K8/365A61K8/49A61K9/00A61K31/19A61K31/535A61K31/56A61K31/573A61K45/06A61P17/08A61Q19/00
CPCA61K8/365A61K8/49A61Q19/00A61K47/44A61K45/06A61K31/573A61K31/56A61K31/535A61K31/19A61K9/0014A61K2300/00A61K31/5375A61P17/00A61P17/08A61P23/00A61P29/00A61K8/31A61K8/345A61K8/361A61K8/368A61K8/73A61K2800/524A61Q19/007
Inventor ROOD, GLORIA A.EVENSTAD, KENNETH L.
Owner UPSHER SMITH LABORATORIES INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap