Regions of papilloma virus E1 helicase involved in E1 oligomerization

a helicase and papilloma virus technology, applied in the field of papilloma virus e1 helicase involved in e1 oligomerization, can solve the problems of no effective antiviral treatment for hpv infection, no treatment of all viral particles, and high cost incurred or uncomfortable side effects
US20050287554A1Inactive Publication Date: 2005-12-29BOEHRINGER INGELHEIM CANADA LTD
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BOEHRINGER INGELHEIM CANADA LTD
Publication Date
2005-12-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

There is provided an amino acid sequence comprised within the PV E1 protein region A delineated by amino acids 352 and 439, and any derivative variant or fragment thereof, necessary for the oligomerization of the E1 protein. This amino acid sequence is capable of self-association and of associating with the full length E1 protein and any derivative, variant or fragment thereof comprising the sequence of this invention. A specific aspect of this first embodiment, the amino acid domain of this invention delimited by amino acids 353 to 438 of the PV E1 protein. More particularly, the amino acid domain of this invention is as defined by SEQ ID NO. 2. There is also provided a cross-linking assay to directly measure the level of oligomerization (or inhibition thereof) of the E1 protein. In accordance with a fourth embodiment of this invention, there is provided a N-terminally truncated E1 protein. More particularly, one aspect of this fourth embodiment encompasses the E1 protein delimited by amino acid 72 to 649 (SEQ ID NO. 78).
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Description

RELATED APPLICATIONS

[0001] This application is a continuation of U.S. Ser. No. 10 / 339,268, filed Jan. 9, 2003 which is a division of U.S. Ser. No. 09 / 744,202, now abandoned, filed Jan. 19, 2001, which is a national stage application of PCT / CA99 / 00657, filed on Jul. 20, 1999, which claims the benefit under 35 USC 119(e) of U.S. Provisional Application Ser. No. 60 / 093,626, filed on Jul. 21, 1998, the disclosures of all of which are incorporated by reference in their entireties.FIELD OF THE INVENTION

[0002] The present invention relates to an amino acid sequence comprised in the papilloma virus E1 protein, necessary for the homo-oligomerization of the E1 protein. This oligomerization, is an essential step in the initiation of viral DNA replication. Further, the invention discloses a screening method and a screening system capable of selecting agents capable of interfering with this protein-protein interaction. Moreover, the invention further relates to a system for the selection of ag...

Claims

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