Nucleic acid and amino acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics

a technology of bacteroides fragilis and amino acids, applied in the field of isolated nucleic acids and polypeptides derived from bacteroides fragilis, can solve problems such as failure of these treatments

Inactive Publication Date: 2006-04-06
GENOME THERAPEUTICS
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  • Abstract
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AI Technical Summary

Benefits of technology

[0016] A variety of data storage structures are available to a person skilled in the art for creating a computer readable media having recorded thereon a nucleotide sequence of the present invention. The choice of the data storage structure will generally be based on the means chosen to access the stored information. In addition, a variety of data processor programs and formats can be used to store the nucleotide sequence information of the present invention on computer readable media. The sequence infor...

Problems solved by technology

The increasing resistance to antibiotics commonly used against B...

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  • Nucleic acid and amino acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics
  • Nucleic acid and amino acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics

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Determination of Bacteroides Protein Antigens for Antibody and Vaccine Development

[0159] The selection of Bacteroides protein antigens for vaccine development can be derived from the nucleic acids encoding B. fragilis polypeptides. First, the ORF's can be analyzed for homology to other known exported or membrane proteins and analyzed using the discriminant analysis described by Klein, et al. (Klein, P., Kanehsia, M., and DeLisi, C. (1985) Biochimica et Biophysica Acta 815, 468-476) for predicting exported and membrane proteins.

[0160] Homology searches can be performed using the BLAST algorithm contained in the Wisconsin Sequence Analysis Package (Genetics Computer Group, University Research Park, 575 Science Drive, Madison, Wis. 53711) to compare each predicted ORF amino acid sequence with all sequences found in the current GenBank, SWISS-PROT and PIR databases. BLAST searches for local alignments between the ORF and the databank sequences and reports a probability score which ind...

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Abstract

The invention provides isolated polypeptide and nucleic acid sequences derived from Bacteroides fragilis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.

Description

RELATED APPLICATIONS [0001] This application is a divisional of U.S. application Ser. No. 09 / 540,209, filed Apr. 4, 2000 which claims the benefit of U.S. Provisional Application No. 60 / 128,705, filed Apr. 9, 1999, the entire teachings of which are incorporated herein by reference.FIELD OF THE INVENTION [0002] The invention relates to isolated nucleic acids and polypeptides derived from Bacteroides fragilis that are useful as molecular targets for diagnostics, prophylaxis and treatment of pathological conditions, as well as materials and methods for the diagnosis, prevention, and amelioration of pathological conditions resulting from bacterial infection. BRIEF DESCRIPTION OF TABLE 2 [0003] Incorporated herein by reference in its entirety is Table 2, comprising Line 1 to Line 10444. Table 2 contained on a CD-ROM, two copies of which are filed, the Table being in a computer-readable ASCII file “Table 2.txt” created on Feb. 24, 2005 and of 583 bytes in size, in IBM-PC Windows®NT v4.0 fo...

Claims

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Application Information

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IPC IPC(8): A61K39/02C12Q1/68C07H21/04C12N15/74C12N1/21C07K14/32
CPCA61K39/00C07K14/195C12Q1/689Y10S977/924
Inventor BRETON, GARY
Owner GENOME THERAPEUTICS
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