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Stent with coatings containing self-assembled monolayers

Inactive Publication Date: 2006-08-10
ABBOTT CARDIOVASCULAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010] In view of the foregoing, coatings for reducing the rate of release a therapeutic substance from implantabl

Problems solved by technology

A problem associated with the above procedure includes formation of intimal flaps or torn arterial linings which can collapse and occlude the conduit after the balloon is deflated.
In order to provide an efficacious concentration to the treated site, systemic administration of such medication often produces adverse or toxic side effects for the patient.

Method used

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  • Stent with coatings containing self-assembled monolayers
  • Stent with coatings containing self-assembled monolayers
  • Stent with coatings containing self-assembled monolayers

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0059] A first composition can be prepared by mixing the following components:

[0060] (a) about 0.4 g of PBMA-HEMA, having a number average molecular weight of about 207,000 and a weight average molecular weight of about 378,000, with the molar ratio between the butylmethacrylate-derived units and the hydrbxyethyl methacrylate-derived units of about 3:1;

[0061] (b) about 11.568 g of acetone;

[0062] (c) about 7.712 g of xylene; and

[0063] (d) about 0.32 g of EVEROLIMUS.

[0064] The first composition can be applied onto the surface of a 13 mm TETRA stent (available from Guidant Corp.) by spraying and dried to form a drug-polymer layer. A spray coater having an EFD 7803 spray valve with 0.014 inch fan nozzle with a VALVEMATE 7040 control system, manufactured by EFD, Inc. of East Providence, R.I. can be used. The feed pressure can be about 0.2 atm (about 3 psi) and an atomization pressure can be about 1.35 atm (about 20 psi). The drug-polymer layer can be baked at about 80° C. for about ...

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Abstract

A medical device with a coating, particularly a drug eluting stent, is described. The coating includes a self-assembled monolayer.

Description

CROSS REFERENCE [0001] This is a divisional application of U.S. Ser. No. 10 / 255,911, which was filed on Sep. 26, 2002.BACKGROUND [0002] 1. Field of the Invention [0003] This invention is directed to coatings for implantable medical devices, such as drug eluting vascular stents. [0004] 2. Description of the State of the Related Art [0005] Percutaneous transluminal coronary angioplasty (PTCA) is a procedure for treating heart disease. A catheter assembly having a balloon portion is introduced percutaneously into the cardiovascular system of a patient via the brachial or femoral artery. The catheter assembly is advanced through the coronary vasculature until the balloon portion is positioned across the occlusive lesion. Once in position across the lesion, the balloon is inflated to a predetermined size to radially compress against the atherosclerotic plaque of the lesion to remodel the lumen wall. The balloon is then deflated to a smaller profile to allow the catheter to be withdrawn f...

Claims

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Application Information

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IPC IPC(8): A61K31/4745A61F2/00
CPCA61K31/4745A61L31/10A61L31/16Y10T428/24B82Y30/00B82Y40/00A61L2300/416
Inventor DING, NI
Owner ABBOTT CARDIOVASCULAR
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