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Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers

a technology of bisphosphonates and amino acids, applied in the field of pharmaceutical compositions, can solve the problems of limited delivery of active agents, and achieve the effect of facilitating absorption of bisphosphonates

Inactive Publication Date: 2007-03-01
EMISPHERE TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013] (b) a modified amino acid carrier, or a pharmaceutically acceptable salt thereof, which modified amino acid carrier is present in an amount effective to facilitate absorption of the bisphosphonate in the gastrointestinal tract such that the bisphosphonate is therapeutically effective;

Problems solved by technology

Delivery of an active agent is often limited by biological, chemical, and / or physical barriers.

Method used

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  • Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers
  • Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers
  • Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0076] In this example, 30 mg film coated ibandronic acid tablets were prepared wherein the ratio of ibandronic acid to sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC) was 1:5.

Formulation CompositionItem#Ingredientmg per TabletKernel Composition1.Ibandronate Monosodium Salt Monohydrate33.7512.Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate161.8123.Lactose Monohydrate (Pharmatose ® 350)17.504.Croscarmellose Sodium (Ac-Di-Sol ®)13.445.Polyvinylpyrrolidone (Povidone; PVP K30)30.506.Purified Water3q.s.7.Croscarmellose Sodium (Ac-Di-Sol ®) (External)9.258.Sodium Stearyl Fumarate (External)3.75Total Weight of Kernel270.00Coating Composition9.Opadry White YS-1-700205.5010.Purified Water3q.s.Total Weight of Film Coated Tablet275.50

1Equivalent to 30 mg of anhydrous ibandronic acid. The quantity of ibandronic acid is to be adjusted if the assay is less than 100%. If the assay adjustment is required, the quantity of Pharmatose ® 350 is reduced to compensate for the increase in ibandronic ...

example 2

[0080] In this example, 30 mg film coated ibandronic acid tablets were prepared wherein the ratio of ibandronic acid to sodium N-[8-(2-hydroxybenzoyl) amino]caprylate (SNAC) was 1:10.

Formulation CompositionItem#Ingredientmg per TabletKernel Composition1.Ibandronate Monosodium Salt Monohydrate33.7512.Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate323.6323.Lactose Monohydrate (Pharmatose ® 350)35.004.Croscarmellose Sodium (Ac-Di-Sol ®)25.625.Polyvinylpyrrolidone (Povidone; PVP K30)61.006.Purified Water3q.s.7.Croscarmellose Sodium (Ac-Di-Sol ®) (External)18.508.Sodium Stearyl Fumarate (External)7.50Total Weight of Kernel505.00Coating Composition9.Opadry White YS-1-700210.5010.Purified Water3q.s.Total Weight of Film Coated Tablet515.50

1Equivalent to 30 mg of anhydrous ibandronic acid. The quantity of ibandronic acid is to be adjusted if the assay is less than 100%. If the assay adjustment is required, the quantity of Pharmatose ® 350 is reduced to compensate for the increase in ibandron...

example 3

[0084] In this example, 30 mg film coated ibandronic acid tablets were prepared wherein the ratio of ibandronic acid to sodium N-[8-(2-hydroxybenzoyl)amino] caprylate (SNAC) was 1:20.

Formulation CompositionItem#Ingredientmg per TabletKernel Composition1.Ibandronate Monosodium Salt Monohydrate33.7512.Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate647.2523.Lactose Monohydrate (Pharmatose ® 350)70.004.Croscarmellose Sodium (Ac-Di-Sol ®)50.005.Polyvinylpyrrolidone (Povidone; PVP K30)122.006.Purified Water3q.s.7.Croscarmellose Sodium (Ac-Di-Sol ®) (External)37.008.Sodium Stearyl Fumarate (External)15.00Total Weight of Kernel975.00Coating Composition9.Opadry White YS-1-700220.0010.Purified Water3q.s.Total Weight of Film Coated Tablet995.00

1Equivalent to 30 mg of anhydrous ibandronic acid. The quantity of ibandronic acid is to be adjusted if the assay is less than 100%. If the assay adjustment is required, the quantity of Pharmatose ® 350 is reduced to compensate for the increase in ibandr...

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Abstract

The present invention provides novel solid pharmaceutical dosage forms for oral administration comprising a bisphosphonate, or a pharmaceutically acceptable salt thereof, which bisphosphonate is present in an amount not therapeutically effective when the bisphosphonate is orally administered alone; and a modified amino acid carrier, or a pharmaceutically acceptable salt thereof, which modified amino acid carrier is present in an amount effective to facilitate absorption of the bisphosphonate in the gastrointestinal tract such that the bisphosphonate is therapeutically effective. The ratio of bisphosphonate to modified amino acid carrier is from about 1:30 to about 1:1, respectively. These novel solid pharmaceutical dosage forms are useful in the treatment or control of bone diseases and particular disorders in calcium metabolism, including, for example, osteoporosis, hypercalcaemia of cancer, and the treatment of metastatic bone pain. The present invention also provides a method for treating these diseases employing the solid pharmaceutical dosage forms and a method for preparing the pharmaceutical dosage forms.

Description

PRIORITY TO RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Application No. 60 / 710,899, filed Aug. 24, 2005 and U.S. Provisional Application No. 60 / 763,982, filed Feb. 1, 2006. The entire contents of the above-identified applications are hereby incorporated by reference.FIELD OF THE INVENTION [0002] The present invention relates to pharmaceutical compositions and methods for making same. BACKGROUND OF THE INVENTION Bisphosphonates [0003] Bisphosphonates (diphosphonates) are synthetic compounds characterized by two carbon to phosphorus bonds: (HO)2(O)P—C(R1)(R2)—P(O)(OH)2 [0004] Bisphosphonates are analogs of inorganic pyrophosphate. (HO)2(O)P—O—P(O)(OH)2 [0005] Inorganic pyrophosphate is a normal by-product of human metabolism and is produced by anabolic processes. Inorganic pyrophosphate is readily hydrolyzed to its constituent phosphate groups. When the linking oxygen atom in the pyrophosphate molecule is replaced by a carbon atom, the bisphosp...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/675A61K31/663
CPCA61K9/1617A61K9/2013A61K9/2866A61K9/48A61K47/32A61K31/663A61K31/675A61K47/183A61K9/501A61P19/00A61P19/10A61P35/04
Inventor AHMED, HASHIMBENDER, LEWISINFELD, MARTIN HOWARDMAJURU, SHINGAIPHUAPRADIT, WANTANEESHAH, NAVNIT HARGOVINDASYU, ZHONGSHUI
Owner EMISPHERE TECH INC
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