Gastric acid secretion inhibiting composition

a technology of gastric acid and composition, applied in the direction of drug composition, dispersed delivery, antibacterial agents, etc., can solve the problems of not providing symptom resolution, e. complete relief of symptoms, etc., and achieve the effect of quick and lasting reli
US20080031941A1Inactive Publication Date: 2008-02-07OREXO AB
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
OREXO AB
Publication Date
2008-02-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

An oral pharmaceutical dosage form comprises pharmacologically effective amounts of an acid susceptible proton pump inhibitor or a salt thereof, an H2 receptor antagonist or a salt thereof and a pharmaceutically acceptable carrier. The dosage form is capable of raising gastric pH to above 4 within two hours after administration and to keep it at that level for at least 4 hours. Also disclosed is a method of manufacture of the dosage form, its use in treating dyspepsia and infection by Helicobacter pylori, and a method of treating disorders associated with gastric acid secretion.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to a gastric acid secretion inhibiting composition, to a method for its manufacture and to its use in treating conditions which are related to the secretion of gastric acid. BACKGROUND OF THE INVENTION

[0002] Dyspepsia (acid dyspepsia) is a common disorder. Heartburn is a symptom of dyspepsia. It is estimated that 44% of Americans have heartburn at least once monthly but that only about 25% of them are seeing the doctor because of their dyspepsia problem. Symptoms associated with dyspepsia are for instance upper abdominal pain / discomfort and heartburn, indigestion, “sour” stomach, and gastro-esophageal reflux.

[0003] Dyspepsia is a multi-factorial disease and may be associated with organic pathology such as duodenal ulcer, gastric ulcer, esophagitis, Barrett's esophagus or gastro-duodenal inflammation (e.g., Helicobacter pylori infection). Dyspepsia also includes conditions where no organic pathology can be found, e.g., non...

Claims

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