Compositions and Methods for Tissue Repair with Extracellular Matrices

US20110189140A1Inactive Publication Date: 2011-08-04RGT UNIV OF CALIFORNIA
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
RGT UNIV OF CALIFORNIA
Publication Date
2011-08-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

Described herein are compositions comprising decellularized cardiac extracellular matrix and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damaged or ischemic cells, tissues or organs in a subject, preferably a human, using a decellularized cardiac extracellular matrix of the invention are provided. Methods of preparing cardiomyocyte culture surfaces and culturing cells with absorbed decellularized cardiac extracellular matrix are provided.
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Description

CROSS REFERENCES TO RELATED APPLICATIONS

[0001] This patent application is a continuation of PCT Application No. PCT / US2009 / 039823, filed Sep. 30, 2009, which claims priority benefit of U.S. Provisional Application No. 61 / 101,332 filed Sep. 30, 2008, each of which is incorporated herein by reference in their entireties.STATEMENT OF GOVERNMENT INTEREST

[0002] This invention was made with government support under grant No. OD004309 awarded by National Institutes of Health (NIH). The government has certain rights in the invention.BACKGROUND

[0003] Various publications, including patents, published applications, technical articles and scholarly articles are cited throughout the specification. Each of these cited publications is incorporated by reference herein, in its entirety.

[0004] Cardiovascular disease is the leading cause of death in the United States. The most common cause of cardiovascular disease is myocardial infarction (MI), which occurs when a coronary artery is occluded. MI results...

Claims

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