Biopharmaceutical plant in a column

Abstract

The present invention relates to a series of therapeutic material processing devices stacked into a column, hereby creating a bio material process plant with extremely small foot-print and all the processing devices being of single-use capabilities for lowest possible cost and methods of operating said column.

Description

TECHNICAL FIELD[0001]The present invention relates to a set of therapeutic material multifunctional processing highly flexible devices stacked in a column, hereby creating a process plant with extremely small foot-print and where preferably all processing devices are of single-use capabilities in order to obtain lowest possible costs. The present invention also relates to methods for continued operation of said bioreactor.BACKGROUND OF THE INVENTION[0002]Disposable bioreactors were considered a novelty, and perhaps even a passing trend, as recently as mid 90ties. As single-use bioreactors and filters have matured and begun to address most of these issues, their market acceptance has rapidly expanded. The development of disposable bioreactors and filters is, in many instances, driven by reduction in sterilisation and cleaning requirements, improved plant flexibility, reduced costs and faster time to market for the end product. Recently, all of these benefits have been well documented...

AI Technical Summary

Benefits of technology

"The present invention provides a flexible and cost-effective way to develop and manufacture biopharmaceutical products. It involves a set of therapeutic material multifunctional processing highly flexible devices that can be quickly and easily assembled in a stack. The invention allows for the evaluation of different configurations faster, as all processing devices are single-use and can be easily disposed of. The invention also provides a complete plant-in-a-Stack that can be sued for all biopharmaceutical systems, including drug manufacturing, enzymes, vaccines, and food ingredients. The invention solves the problem of increased flexibility and cost-effectiveness by integrating different capsules into a column that operates on a continuous basis. The invention allows for the development of a bioreactor with increased compactness and reduces the cost of manufacturing production facilities needed for industrial scale bio-fermentation."

Problems solved by technology

There is no such thing available on the market or described in the patent literature, as disposable bioreactors or disposable fluid pumps, sensors, heating, conditioning, sparging devices, oxygenating devices integrated into capsules for stacking purposes into a bio factory.

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