Laser-induced acoustic desorption / atmospheric pressure chemical ionization of compounds

a chemical ionization and acoustic desorption technology, applied in the field of new materials, can solve the problems of difficult study of esi and maldi, and is not ideal for studying non-polar compounds in their natural sta

Inactive Publication Date: 2011-11-10
PURDUE RES FOUND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ESI and MALDI methods are biased toward polar and ionic compounds and are therefore not ideal for studying non-polar compounds in their natural state.
Additionally, the ionization of analytes in ESI and MALDI is limited to protonation, deprotonation, or cation attachment, thus the study of nonpolar compounds remains difficult.
Further, ESI and MALDI methods are not suited for ionizing analytes which do not comprise easily ionizable functional groups, such as saturated and unsaturated hydrocarbons [1].

Method used

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  • Laser-induced acoustic desorption / atmospheric pressure chemical ionization of compounds
  • Laser-induced acoustic desorption / atmospheric pressure chemical ionization of compounds
  • Laser-induced acoustic desorption / atmospheric pressure chemical ionization of compounds

Examples

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example 1

Selection of Experimental Compounds for Ionization and Mass Spectrometer Measurement

[0056]To evaluate the performance of the disclosed system and method utilizing the above described combination and orientations of LIAD source 16 and ionization source 12, five known model compounds of different types (illustrated in Scheme 1) were analyzed according to the system and method disclosed herein. The selected compounds are structurally similar to compounds commonly present in petroleum, ranging from hydrocarbons to polar compounds. As described herein, all five analytes were successfully evaporated into ionization chamber 31 of mass spectrometer system 10 by way of with LIAD source 16. Further, although it should be understood that any of the embodiments described herein may be utilized, the Examples provided herein were performed using the embodiments depicted in FIG. 1B comprising APCI source 12′.

[0057]Further described herein these examples, three different APCI solvent systems (a. me...

example 2

Ionization and Mass Spectrometry of Bathophenanthroline

example 2.1

Solvent System of Methanol and Water Mixture (1:1, v / v)

[0058]Bathophenanthroline was deposited on foil 14 in accordance with the manners described above. Use of APCI solvent system of methanol and water (1:1, v / v) in conjunction with APCI source 12 for ionization of bathophenanthroline yielded only protonated methanol and its cluster ion, H+(CH3OH)2. The mixture of protonated methanol and H+(CH3OH)2 ionized evaporated analytes. Mass spectrometry system 10 results of the heteroaromatic analyte bathophenanthroline (FIG. 2), ionized according to the instant disclosure, resulted in production of only stable protonated molecules.

[0059]With reference to FIG. 2, LIAD / APCI positive ion mass spectrum of bathophenanthroline is shown. FIG. 2 represents ionization of bathophenanthroline according to the instant disclosure using a methanol and water (1:1, v / v) APCI solvent system. As shown by the positive ion mass spectrum of FIG. 2, ionization of bathophenanthroline according to the instant dis...

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Abstract

The present disclosure provides a novel system and method for evaporating and ionizing compounds comprising an LIAD source and an ionization source that operates at atmospheric pressure. This system is readily adaptable for use with most commercially available mass spectrometers. Ionization sources include Atmospheric Pressure Chemical Ionization sources (APCI) and Atmospheric Pressure Photo Ionization (APPI) sources. The ionization sources are positioned such that the analyte desorbing from the surface of the LIAD is fed into the ion stream produced by the ionization source and ionized analyte and ionized fragments of the analyte are fed into the sample inlet of a mass spectrometer. These systems allow for the mass spectrometric analysis of non-polar compounds that lack readily ionizable functional groups, such as saturated and unsaturated hydrocarbons and compounds with medium to low polarity, as well as hydrocarbon mixtures, such as petroleum.

Description

PRIORITY CLAIM[0001]This application claims the benefit of U.S. provisional patent application No. 61 / 320,917 filed on Apr. 5, 2010, which is hereby incorporated by reference in its entirety.STATEMENT OF GOVERNMENT RIGHTS[0002]This invention was made with government support from the National Institutes of Health under grant number R01GM052418 and the National Science Foundation under grant number CHE-0911629. The U.S. government has certain rights in the invention.FIELD OF THE DISCLOSURE[0003]The present disclosure relates to a novel system and method for evaporating and ionizing compounds. More particularly, the present disclosure relates to the use of acoustic desorption coupled to an atmospheric pressure ionization source in a mass spectrometer.BACKGROUND OF THE DISCLOSURE[0004]Mass spectrometry, in general, is a powerful technique for detection of minute or trace levels of compounds, and combinations thereof. With the development of electrospray ionization mass spectrometry (ESI...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): H01J49/10H01J27/02H01J49/40H01J49/26
CPCH01J49/0463H01J49/0454
Inventor KENTTAMAA, HILKKA I.BORTON, II, DAVID JESSEGAO, JINSHANJIN, ZHICHENGOWEN, BENJAMIN CURTIS
Owner PURDUE RES FOUND INC
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