Nano-Scale Coatings and Related Methods Suitable for In-Vivo Use

a nano-scale coating and nano-scale technology, applied in the field of therapeutic agents, can solve the problems of affecting the structural stability/or the ability of the nano-scale device, and the creation of therapeutic agent delivery devices capable of delivering therapeutic agents in controlled ways

Inactive Publication Date: 2011-11-24
NANOMEDICAL SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0023]Certain embodiments comprise a method of providing dimensional stability to a nano-scale device, where the method comprises forming the nano-scale device with a first material that is not bio-robust, and coating the first material with a second material that is bio-robust. In particular embodiments, the nano-scale device comprises a nanochannel delivery device.

Problems solved by technology

The creation of therapeutic agent delivery devices that are capable of delivering therapeutic agents in controlled ways is still a challenge.
Both the therapeutic agent and the body, however, contain fluids and chemical compounds that may attack over time certain materials used in the construction of an nano-scale device, which can affect the structural stability of the nano-scale device and / or the ability of the nano-scale device to control the release of the therapeutic agent.

Method used

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  • Nano-Scale Coatings and Related Methods Suitable for In-Vivo Use

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Embodiment Construction

[0027]As previously mentioned, in certain applications a nanochannel delivery device may be implanted into a human or animal body. It is therefore desirable that the materials exposed to bio-fluids be resistant to attack from those fluids. In certain applications, materials used in the construction of an NDD may not be resistant to bio-fluids.

[0028]For example, bio-fluids may cause corrosion or erosion of silicon, silicon dioxide and silicon nitride. The NDD embodiments disclosed in the '233 and '937 Applications incorporate silicon nitride and silicon as the “ceiling” and “floor” of the nanochannels. While silicon nitride provides good tensile strength, it does not generally exhibit good corrosion / erosion resistance in certain applications in the human body (11,12)

[0029]Therefore, it can be desirable to provide a coating of material that is “bio-robust” over a material that provides beneficial mechanical strength. As used herein, bio-robust materials include materials configured to...

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Abstract

A nano-scale device and method of manufacturing and use. The nano-scale device may be used in-vivo and may comprise a fluid path with an inlet microchannel, an outlet microchannel, and a nanochannel. The fluid path comprises bio-robust material. In certain embodiments, the bio-robust material may be coated over a material that is not bio-robust.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application Ser. No. 61 / 346,372 filed May 19, 2010 and entitled “Nano-Scale Coatings and Related Methods Suitable for In-Vivo Use”, the entire contents of which are incorporated herein by reference.BACKGROUND INFORMATION[0002]Considerable advances have been made in the field of therapeutic agent (e.g. drug) delivery technology over the last three decades, resulting in many breakthroughs in clinical medicine. The creation of therapeutic agent delivery devices that are capable of delivering therapeutic agents in controlled ways is still a challenge. One of the major requirements for an implantable drug delivery device is controlled release of therapeutic agents, ranging from small drug molecules to larger biological molecules. It is particularly desirable to achieve a continuous passive drug release profile consistent with zero order kinetics whereby the concentration of drug in th...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M25/00C23F1/02B05D3/00B82Y5/00
CPCA61L27/306A61L2300/608B82Y5/00B01L3/502707A61L2400/12A61M31/002A61M2205/0238A61M2205/025A61M2205/04A61M2207/00
Inventor GOODALL, RANDYHOSALI, SHARATH
Owner NANOMEDICAL SYST
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