Method of Screening a Sample for the Presence of One or More Known Compounds of Interest and a Mass Spectrometer Performing this Method

a mass spectrometer and sample technology, applied in the field of screening samples for the presence of one or more known compounds of interest, can solve problems such as unsuitability for use in applications

Active Publication Date: 2012-09-27
MICROMASS UK LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0106]According to an embodiment, a tandem quadrupole orthogonal acceleration Time of Flight mass spectrometer is used in a way in which candidate parent or precursor ions are discovered using a method in which sequential relatively low fragmentation or reaction mass spectra followed by relatively high fragmentation or reaction mass spectra are recorded. The switching back and forth of the collision, fragmentation or reaction device

Problems solved by technology

It is known that these types of mass spectrometers when used to perform conventional methods of obtaining fragment or daughter ion spectrum of a candidate parent or prec

Method used

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  • Method of Screening a Sample for the Presence of One or More Known Compounds of Interest and a Mass Spectrometer Performing this Method
  • Method of Screening a Sample for the Presence of One or More Known Compounds of Interest and a Mass Spectrometer Performing this Method
  • Method of Screening a Sample for the Presence of One or More Known Compounds of Interest and a Mass Spectrometer Performing this Method

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Embodiment Construction

[0122]A preferred embodiment will now be described with reference to FIG. 1. A mass spectrometer 6 is provided which preferably comprises an ion source 1 preferably an Electrospray ionization source. An ion guide 2 is preferably provided downstream of the ion source 1. A quadrupole rod set mass filter 3 is preferably provided downstream of the ion guide 2 and upstream of a collision, fragmentation or reaction device 4. According to an embodiment an orthogonal acceleration Time of Flight mass analyser 5 preferably incorporating a reflectron is preferably provided downstream of the collision, fragmentation or reaction device 4. The ion guide 2 and the mass filter 3 may be omitted if necessary. The mass spectrometer 6 is preferably interfaced with a chromatograph, such as a liquid chromatograph (not shown) so that the sample entering the ion source 1 may be taken from the eluent of the liquid chromatograph.

[0123]The quadrupole rod set mass filter 3 is preferably disposed in an evacuate...

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Abstract

A method of screening a sample for the presence of one or more known compounds of interest is disclosed. A fragmentation device is repeatedly switched between a fragmentation mode of operation and a non-fragmentation mode of operation. A determination is made whether a candidate parent ion of interest is present in a non-fragmentation data set and whether one or more corresponding fragment ions of interest are present in a fragmentation data set. A further determination is made to check if the candidate parent ion of interest and the one or more corresponding fragment ions of interest have substantially similar elution or retention times and/or ion mobility drift times.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority from and the benefit of U.S. Provisional Patent Application Ser. No. 61 / 245,401 filed on 24 Sep. 2009 and United Kingdom Patent Application No. 0915474.1 filed on 4 Sep. 2009. The entire contents of these applications are incorporated herein by reference.BACKGROUND TO THE PRESENT INVENTION[0002]The present invention relates to a method of screening a sample for the presence of one or more known compounds of interest, a method of mass spectrometry and a mass spectrometer.[0003]Tandem mass spectrometry (MS / MS) is the name given to the method of mass spectrometry wherein parent or precursor ions generated from a sample are selected by a first mass filter / analyser and are then passed to a collision cell wherein they are fragmented by collisions with neutral gas molecules to yield daughter or product ions. The fragment or daughter ions are then mass analysed by a second mass filter / analyser and the resulting fra...

Claims

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Application Information

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IPC IPC(8): H01J49/26H01J49/40
CPCH01J49/0027H01J49/40H01J49/004G01N30/72
Inventor GOSHAWK, JEFFREY ALANPRINGLE, STEVEN DEREKSMITH, STEVE
Owner MICROMASS UK LTD
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