Use of an active ingredient combination that contains hydroxystilbene for preventing and/or treating diseases
a technology of active ingredients and hydroxystilbene, which is applied in the direction of biocide, plant ingredients, medical ingredients of coniferophyta, etc., can solve the problems of insufficient investigation of whether, metabolites, and the constituents of err 731® are degraded in the body, and do not provide verifiable technical teaching of the asserted pharmacological usability
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Benefits of technology
Problems solved by technology
Method used
Image
Examples
preparation example 1
Preparation of the Dry Extract ERr 731 from Rhapontic Rhubarb Root with an Aqueous Calcium Hydroxide Solution
[0202]A dry extract is prepared from rhapontic rhubarb root employing the following:
Drug (radix rheum rhaponticum) 50.0 kgCalcium oxide 5.0 kgPurified water190.0 kgAcetic acid (as necessary to adjust the required pH)
[0203]The yield which can be achieved in this case is between 2 and 3 kg per 50 kg of drug.
[0204]The preparation takes place in the following steps:
[0205]a) Firstly 5 kg of calcium oxide are introduced into a plastic tub and made into a slurry with 20 kg of purified water. The formation of calcium hydroxide (quicklime) which takes place under these conditions leads to a large rise in temperature of the solution. The calcium hydroxide can therefore be used further only after cooling. The temperature of the solution is then 30° C. to 35° C.
[0206]b) 50 kg of drug are introduced into a mixer, and the abovementioned quicklime is added. In order to remove the quicklime ...
preparation example 2
Preparation of a Dry Extract from Rhapontic Rhubarb Root with Various Organic Solvents
[0215]The constituents mainly detectable in the rhapontic rhubarb root used as drug here belong to the group of hydroxystilbenes. Present from this group in the roots are rhaponticin (Rh) with a content of about 6% and deoxyrhaponticin (DRh) with a content of about 4%.
[0216]It is possible by exposure to the solvent systems indicated below, in a 100-fold quantity at room temperature for 10 minutes with shaking or stirring, to extract the proportions summarized below:
Ethanol 86%Rh100.8%DRh99.5%Ethanol 15%Rh77.1%DRh75.5%AcetoneRh88.3%DRh96.6%Water, alkalineRh75.5%(pH 11, adjusted with CaO solution)DRh60.5%
[0217]No useful results were achieved with heptane.
[0218]The respective yields of crude extracts in proportions by mass (based on drug employed) are as follows:
Ethanol 86%35.5%Ethanol 15%32.2%Acetone21.4%Heptane 0%Water, alkaline 4.5%
[0219]Extraction of rhapontic rhubarb root with ethanol-water mixt...
formulation example 1
Production of a Solid Dosage Form—Minitablet
[0223]1. Production of the tablet core:
[0224]A solid tablet core is produced using the following active ingredients and ancillary substances in the stated ratios of amounts (P=parts by weight). The ingredients are mixed and tabletted in three different ways:
[0225]a) Tablet core formulation:
Purified dry extract according to3.6Ppreparation example 1 fromrhapontic rhubarb root (ERr 731 ®)Microcrystalline cellulose (e.g. Avicel ®)57.0P (±40%)Sorbitol8.0P (±40%)Talc2.5P (±40%)Makrogol 6000 (polyglycol)1.6P (±40%)Polyvidone (K value about 25, e.g. Kollidon ® 25)1.6P (±40%)Sodium dodecyl sulfate (e.g. Texapon ® K 12)0.5P (±40%)Magnesium stearate (vegetable)0.8P (±40%)75.6P (±40%)
[0226]It is possible by varying the weighed amount of ERr 731® and / or varying the amount of microcrystalline cellulose to obtain any desired ERr 731® contents in the untreated core (such as, for example, 2, 4, 6, 8, 10, 12 mg per tablet).
[0227]b) Mixing of drug and carrie...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More