Processes, systems, and apparatus for cyclotron production of technetium-99m
a technology of cyclotron and cyclotron, which is applied in the field of processes, systems and apparatus, for the production of cyclotron, can solve the problems of serious on-going world-wide shortage of mo-99 for medical facilities and discrepancies in conversion efficiency
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[0037]An exemplary embodiment of the present disclosure pertains to processes for producing Tc-99m by low-energy proton radiation of Mo-100 using proton beams produced by accelerators such as cyclotrons. Suitable proton energy for the processes of the present disclosure is from a range of about 10 MeV to about 30 MeV incident on the target. A flowchart outlining an exemplary process is shown in FIG. 1. The process generally follows the steps of:
[0038]1) Processing a supply of enriched Mo-100 metal powder to produce a Mo-100 powder with a consistent grain size of less than about 10 microns.
[0039]2) Depositing a coating of the processed Mo-100 powder onto a target plate comprising a transition metal, by electrochemical and / or electrophoretic deposition.
[0040]3) Sintering the coated target plate in an inert atmosphere for about 2 hours to about 10 hours at a temperature of about 1200° C. to about 2000° C.
[0041]4) Securely engaging the sintered target plate into a target holder. A targe...
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Abstract
- (i) irradiating in a substantially oxygen-free environment, a hardened sintered target plate coated with a Mo-100 metal, with protons produced by a cyclotron;
- (ii) dissolving molybdenum ions and technetium ions from the irradiated target plate with an H2O2 solution to form an oxide solution;
- (iv) raising the pH of the oxide solution to about 14;
- (v) flowing the pH-adjusted oxide solution through a resin column to immobilize K[TcO4] ions thereon and to elute K2[MoO4] ions therefrom;
- (vi) eluting the bound K[TcO4] ions from the resin column;
- (vii) flowing the eluted K[TcO4] ions through an alumina column to immobilize K[TcO4] ions thereon;
- (viii) washing the immobilized K[TcO4] ions with water;
- (ix) eluting the immobilized K[TcO4] ions with a saline solution; and
- (x) recovering the eluted Na[TcO4] ions.
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