Method for peptide histochemical diagnosis

a histochemical diagnosis and peptide technology, applied in the field of peptide histochemical diagnosis, can solve the problems of difficult to identify whether the peptide is present, poor result in paraffin-embedded surgical specimens, and inability to anticipate the efficacy of chemotherapy for cancer patients after surgery using this method, and achieves the effect of a small volume and more binding ability
US20150111226A1Inactive Publication Date: 2015-04-23NAT TAIWAN UNIV
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Patent Information

Authority / Receiving Office
US ¡ United States
Current Assignee / Owner
NAT TAIWAN UNIV
Publication Date
2015-04-23
Estimated Expiration
Not applicable ¡ inactive patent

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Abstract

The present invention provides a method of peptide histochemical diagnosis to detect the peptide binding protein in the cancer tissue. This peptide binding specifically to tumor cells is linked to the dextran coated iron oxide nanoparticle. The peptide linked dextran coated iron oxide nanoparticle can be used to bind to the formalin-fixed and paraffin-embedded tumor surgical specimens, and the method of present invention can be used to evaluate the efficacy of peptide-targeted chemotherapy for treatment of cancer patients.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the priority benefit of Taiwan application serial no. 102137765, filed on 18 Oct. 2013. The disclosure of the Taiwan application is incorporated by reference herein.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The invention relates to a method for peptide histochemical diagnosis, and in particular, to a method for peptide histochemical diagnosis of the formalin-fixed paraffin-embedded surgical specimens.

[0004] 2. The Prior Arts

[0005] Currently, some targeted peptides for the targeted chemotherapy in cancers have been reported. However, it is difficult to identify whether the peptides can be used to bind to the peptide binding protein in cancer cells by staining the formalin-fixed paraffin-embedded surgical specimens, to confirm the peptides for the targeted chemotherapy in cancers has efficacy in patients before clinical use. Although the patients suffer the same type of cancer, it is still unknown...

Claims

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