Drug mixing and delivery system and method

a technology of drug mixing and delivery system, applied in the direction of drug composition, peptide/protein ingredient, metabolic disorder, etc., can solve the problems of hives, anaphylactic shock, sharp drop in blood pressure, etc., to improve stability, potency and/or chiral stability, and long shelf life

Inactive Publication Date: 2015-08-20
WINDGAP MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]In some embodiments, aspects of the invention relate to dry drug compositions (e.g., dry powder compositions) that can be dissolved and/or reconstituted rapidly for delivery to a patient (e.g., a human patient). According to as

Problems solved by technology

Exposure to certain substances, such as, for example, peanuts, shellfish, bee venom, certain drugs, toxins, and the like, can cause allergic reactions in sensitive individuals.
Such allergic reactions can lead to anaphylactic shock.
This can cause a sharp drop in blood pressure, hives, and/or severe airway constriction and can be a

Method used

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  • Drug mixing and delivery system and method
  • Drug mixing and delivery system and method
  • Drug mixing and delivery system and method

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Embodiment Construction

[0035]Provided herein are methods of preparing a medical solution comprising a therapeutic agent. In some embodiments, aspects of the invention relate to stabilizing a drug and making it less susceptible to temperature-induced degradation, by preparing a dry composition (e.g., a dry salt form) of the drug that can be readily reconstituted (e.g., in the context of an autoinjector) for delivery to a patient.

[0036]The dry composition can be prepared from any suitable method as used in the pharmaceutical formulation. For example, a drug may be chemically derived, lyophilized (freeze-dried) and / or spray dried and / or using any other technique to put the drug and / or medicament into a dry form. However, in some embodiments, it is important that the dried drug be easily and rapidly soluble so that the dry composition can be used in an autoinjector that also contains a liquid component that can be mixed with the dry drug to solubilize it upon activation of the autoinjector (e.g., immediately ...

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Abstract

The present disclosure provides methods of preparing a medical solution. In some aspects, the medical solution can be prepared from mixing a first liquid with a second liquid or mixing a solid component with a liquid in an autoinjector. In some aspects, the heat released from the mixing can promote solubility of a dry medicament in the solution.

Description

RELATED APPLICATIONS[0001]The present invention claims priority under 35 U.S.C. §119(e) to U.S. provisional patent applications, U.S. Ser. No. 61 / 917,925, filed Dec. 18, 2013, and U.S. Ser. No. 62 / 016,260, filed Jun. 24, 2014, the entire contents of each of which are incorporated herein by reference.BACKGROUND OF INVENTION[0002]Individuals who suffer from certain medical conditions are often required to keep an auto-injector or prefilled syringe nearby in order to address a medical need. A few examples of this are insulin pens for people with diabetes, epinephrine autoinjectors for those with food and insect stings allergies, and antidotes for soldiers at risk of exposure to chemical and / or biological toxins in the field.[0003]Exposure to certain substances, such as, for example, peanuts, shellfish, bee venom, certain drugs, toxins, and the like, can cause allergic reactions in sensitive individuals. Such allergic reactions can lead to anaphylactic shock. This can cause a sharp drop...

Claims

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Application Information

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IPC IPC(8): A61M5/24A61M5/28A61K31/4045A61K31/137A61K38/26
CPCA61K31/137A61K38/00A61K45/06A61K31/4045A61K9/0019A61M5/19A61M5/2046A61M5/3294A61M5/44A61M2205/364A61M2205/366A61M5/1409A61K38/26A61P25/06A61P3/08A61P9/02A61M5/2448A61M5/284
Inventor BUCHINE, BRENT A.STANDLEY, ADAM R.STEPANIAN, CHRISTOPHER J.
Owner WINDGAP MEDICAL
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