Drug mixing and delivery system and method

Abstract

The present disclosure provides methods of preparing a medical solution. In some aspects, the medical solution can be prepared from mixing a first liquid with a second liquid or mixing a solid component with a liquid in an autoinjector. In some aspects, the heat released from the mixing can promote solubility of a dry medicament in the solution.

Description

RELATED APPLICATIONS[0001]The present invention claims priority under 35 U.S.C. §119(e) to U.S. provisional patent applications, U.S. Ser. No. 61 / 917,925, filed Dec. 18, 2013, and U.S. Ser. No. 62 / 016,260, filed Jun. 24, 2014, the entire contents of each of which are incorporated herein by reference.BACKGROUND OF INVENTION[0002]Individuals who suffer from certain medical conditions are often required to keep an auto-injector or prefilled syringe nearby in order to address a medical need. A few examples of this are insulin pens for people with diabetes, epinephrine autoinjectors for those with food and insect stings allergies, and antidotes for soldiers at risk of exposure to chemical and / or biological toxins in the field.[0003]Exposure to certain substances, such as, for example, peanuts, shellfish, bee venom, certain drugs, toxins, and the like, can cause allergic reactions in sensitive individuals. Such allergic reactions can lead to anaphylactic shock. This can cause a sharp drop...

AI Technical Summary

Benefits of technology

The patent relates to a method of making drug compositions that can be quickly dissolved and reconstitutable for delivery to a patient. These dry compositions have several advantages over liquid compositions, including increased stability and shelf life. The dry drug composition is prepared by drying a drug solution using methods like vacuum drying, freeze drying, or lyophilizing. The dry drug can be placed inside an autoinjector as a dry powder and can have a small particle size for efficient and rapid reconstitution. This results in a medicament that can be stored as a dry medication with extended shelf-life, reduced temperature susceptibility, and greater efficacy and potency to endure over a longer period of time and through a wider range of temperature environments.

Problems solved by technology

Exposure to certain substances, such as, for example, peanuts, shellfish, bee venom, certain drugs, toxins, and the like, can cause allergic reactions in sensitive individuals.

Such allergic reactions can lead to anaphylactic shock.

This can cause a sharp drop in blood pressure, hives, and / or severe airway constriction and can be a life-threatening condition.

For patients that are required to carry epinephrine autoinjectors with them, the thermal stability profile of the medication can present an issue.

Not doing so can degrade the medication rapidly and result in a drug that doesn't have the recommended potency to deal with the onsets of anaphylactic shock.

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