Product comprising red clover extract and methods for producing the same

Inactive Publication Date: 2016-01-07
HERRENS MARK APS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0038]Aglycone form of isoflavons: Phenolic compounds from red clover known as isoflavones exist in glycoside or aglycone (without the glycoside part) forms. Fermentation increases isoflavone aglycone content in

Problems solved by technology

The human menopause is associated with increased risk of osteoporosis, negative changes in lipid status, cardiovascular events, vasomotor symptoms and reduced quality of life.
Hormone replacement therapy has however proved to be of lim

Method used

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  • Product comprising red clover extract and methods for producing the same
  • Product comprising red clover extract and methods for producing the same
  • Product comprising red clover extract and methods for producing the same

Examples

Experimental program
Comparison scheme
Effect test

example 1

Production of Red Clover Extract

[0218]Red clovers are harvested and added to a container.

[0219]The red clovers are heated to 70° C. for 1 hour.

[0220]The liquid from the red clovers—i.e. the red clover extract—is extracted from the red clovers by compression of the red clovers. The red clover extract is transferred to a separate container and kept at 3-5° C.

[0221]Lactic acid bacteria are added to the red clover extract.

[0222]The red clover extract will be allowed to be fermented for 6 months. During this period the red clover extract is transferred to a new container every 6 to 8 weeks. The fermentation is performed at 3-5° C.

[0223]The pH of the red clover extract will decrease to about 4 or less than 4 during the fermentation process. The decrease of the pH results in conservation of the red clover extract.

[0224]The red clover extract will subsequently be stable for 1.5 to 2 years.

Analysis of Isoflavone Content in the Red Clover Extract

[0225]Table 1 herein below indicated the conten...

example 2

Clinical Data

Objective

[0226]The aim of this study was to determine whether a three month daily intake of the Red Clover preparation according to the present invention can alleviate hot flush symptoms and associated disorders when compared with placebo.

[0227]The specific objectives of the study comprise:

1) To examine the extent to which Red Clover extract can reduce incidence and intensity of vasomotor symptoms.

2) To examine whether daily Red Clover extract supplementation can reduce bone mineral resorption and help maintain BMD (Bone Mineral Density) in the short term.

3) To assess the effect of Red Clover extract at promoting cardiovascular health, inducing positive lipid profile and reducing inflammatory status.

Method

[0228]Summary of Method

[0229]60 menopausal women were randomly assigned a three month daily Red Clover preparation (with 37.1 mg isoflavones per day) or equivalent placebo. The progressions of the menopause symptomology were evaluated with a variety of methods. Menopau...

example 3

Goal

[0319]The primary scientific goals of the first phase of the project are as follows; 1) to assess the bioavailability of a liquid RC preparation in women in the menopause 2) to determine the efficacy of the RC preparation on menopause symptoms and as a possible attenuator of bone mineral resorption 3) to elucidate the effects of RC on the lipid profile and cardiovascular health of menopausal women. The present study will employ a novel technology (skin conductors) for the measurement of menopausal hot flushes enabling objective physiological measurement of vasomotor symptoms over 24 hours.

[0320]The primary scientific goals for phase two of the project are as follows; 1) to compare the efficacy of a combined RC, vitamin D, calcium and magnesium treatment to the standard treatment (vitamin D, calcium and magnesium) proscribed to women with estrogen deficient osteopenia 2) to identify other benefits to heath occurring with treatment (i.e. lipid profile, cardiovascular health and re...

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Abstract

The invention relates to a composition comprising isoflavones from red clover. The red clover extract has been fermented to obtain a composition comprising aglycone isoflavones. The fermentation is preferably performed by a lactic acid bacteria or fermented dandelion extract.

Description

FIELD OF INVENTION[0001]The invention relates to a composition comprising red clover extract. The red clover extract has been fermented to obtain a composition comprising the aglycone form of isoflavones. The fermentation is preferably performed by a lactic acid bacteria.BACKGROUND[0002]The human menopause is associated with increased risk of osteoporosis, negative changes in lipid status, cardiovascular events, vasomotor symptoms and reduced quality of life. The aetiology of these effects is thought to derive from the deficiency and / or dysregulation of normal estrogen homeostasis caused by the menopause. Hormone replacement therapy with estrogen has proven to be effective in treating osteoporosis and vasomotor symptoms associated with the menopause. Hormone replacement therapy has however proved to be of limited use in this regard due to the inherent problems regarding the side effects of treatment, i.e. increased risks for cancer (breast, endometrial and ovarian), cardiovascular d...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K36/48A61K47/46C12P17/06
CPCA61K31/352C12P17/06A61K47/46A61K36/48A61K35/744A61K36/288A61P15/12A61P19/10A61K2300/00
Inventor JENSEN, MICHAEL MOHRJEPPESEN, PER BENDIXLAMBERT, MAX NORMAN TANDRUPTHORUP, ANNE CATHRINE SONDERSTGAARD
Owner HERRENS MARK APS
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