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Hesperidin-containing compositions and methods for treatment of skin disorders

a composition and composition technology, applied in the field of hesperidin-containing compositions and methods for treating skin disorders, can solve the problems of compromised epidermal barrier function, achieve the effects of reducing sc ph, improving barrier function, and enhancing epidermal proliferation

Inactive Publication Date: 2017-01-26
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a new skincare product that can improve the health of dry, inflamed, or ageing skin. The product contains a combination of two active ingredients, hesperidin and a triple-lipid barrier mixture, which work together to enhance the skin's ability to regulate its own barrier function. The product also needs to have a low pH, between 7 and 7, to be effective and not cause irritation. This skincare product can help prevent and treat common barrier function issues associated with ageing, diabetes, and other skin conditions.

Problems solved by technology

In all of these situations, epidermal barrier function is compromised due to decreased differentiation, proliferation, impaired lipid secretion, or an elevated skin surface pH.

Method used

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  • Hesperidin-containing compositions and methods for treatment of skin disorders
  • Hesperidin-containing compositions and methods for treatment of skin disorders
  • Hesperidin-containing compositions and methods for treatment of skin disorders

Examples

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examples

[0206]Citrus bioflavonoids, such as orange peel extract, reportedly exhibit beneficial effects for skin pigmentation, inflammation, and ultraviolet (UV) protection, as well as stimulating keratinocyte proliferation. We have recently demonstrated that topical hesperidin improves epidermal permeability barrier function in young normal murine skin, and have explored the responsible mechanisms. Topical hesperidin significantly accelerated young murine skin barrier recovery after acute barrier abrogation; which correlated with stimulation of both epidermal proliferation and differentiation, as well as enhanced lamellar body (lipid) secretion. These results indicated that topical hesperidin enhances epidermal permeability barrier homeostasis in normal skin by stimulating epidermal proliferation and differentiation, and by stimulating lamellar body secretion. However, the benefits of topical citrus bioflavonoids such as hesperidin for aged skin have not heretofore been disclosed.

[0207]As n...

embodiments

Embodiment P1

[0258]A topical composition for treating dry skin or skin suffering an abnormal epidermal barrier function, said composition comprising:[0259]a) about 1 to about 50 wt % of cholesterol;[0260]b) about 0.01 to about 5 wt % of an acid buffer; and[0261]c) about 0.001 to about 50 wt % of hesperidin;

wherein the pH of said topical composition is about 3 to about 5.5.

embodiment p2

[0262]A topical composition for treating aged skin, said composition comprising:[0263]a) a mixture of barrier lipids selected from the group consisting of cholesterol, at least one ceramide, at least one free fatty acid, and mixtures of two or more thereof, in a total of about 1 to about 50 wt %;[0264]b) about 0.1 to about 10 wt % of a skin conditioner;[0265]c) about 0.001 to about 5 wt % of a chelating agent;[0266]d) about 1 to about 30 wt % of a humectant;[0267]e) about 0.5 to about 20 wt % of an emulsifier;[0268]f) one or more emollients in a total of about 1 to about 30 wt %;[0269]g) one or more preservatives in a total of about 0.1 to about 10 wt %;[0270]h) about 0.01 to about 5 wt % of an acid buffer;[0271]i) one or more encapsulation aids in a total of about 1 to about 25 wt %;[0272]j) about 0.01 to about 3 wt % of an aqueous phase thickener; and[0273]k) about 0.001 to about 50 wt % of hesperidin.

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Abstract

Compositions and methods for treating aged skin or skin otherwise suffering from abnormal epidermal barrier function are disclosed, where the compositions include hesperidin.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application No. 62 / 120,682, filed Feb. 25, 2015 which is incorporated herein by reference in its entirety and for all purposes.REFERENCE TO A “SEQUENCE LISTING,” A TABLE, OR A COMPUTER PROGRAM LISTING APPENDIX SUBMITTED AS AN ASCII FILE[0002]The Sequence Listing written in file 48536-558001WO_ST25.TXT, created Feb. 18, 2016, 7,435 bytes, machine format IBM-PC, MS-Windows operating system, is hereby incorporated by reference.FIELD OF THE DISCLOSED SUBJECT MATTER[0003]The presently disclosed subject matter relates to topical compositions containing hesperidin, cholesterol alone or as part of a triple physiologic mixture of stratum corneum lipids, formulated at an acidic pH, and their utility for the treatment of: i) dry or aged skin due to an abnormal epidermal permeability barrier; ii) dry skin with an abnormal permeability barrier due to the use of systemic hypolipidemic drugs; iii)...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/72A61Q19/00A61K8/63A61K8/36A61K8/44A61K8/34A61K8/42A61Q19/08A61K8/58
CPCA61K8/72A61Q19/08A61Q19/007A61K8/63A61K8/36A61K8/44A61K8/345A61K8/42A61K8/361A61K8/585A61Q19/00A61K8/365A61K8/602A61K8/68
Inventor ELIAS, PETER M.MAN, MAO-QIANG
Owner RGT UNIV OF CALIFORNIA
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