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Antioxidative stress compositions, methods of preparing and uses thereof

a technology of compositions and compositions, applied in the field of antioxidative stress compositions, can solve the problems of affecting the health of mammals, including humans and their companion animals, being adversely affected by oxidative stress, and affecting the health of service animals and pets, so as to reduce the oxidative stress in mammals, reduce the oxidative stress, and alleviate symptoms.

Inactive Publication Date: 2017-10-26
PEZZUTO JOHN MICHAEL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a composition that can help reduce oxidative stress and has various benefits for mammals. The composition contains various active agents such as resveratrol, genistein, ellagic acid, curcumin, quercetin, and others. These active agents can help prevent damage to DNA, RNA, proteins, and other cellular components caused by oxidative stress. The composition can be used to treat various disorders associated with oxidative stress, including cancer, autoimmune disorders, heart disease, inflammatory disorders, bone disorders, bladder function disorders, joint health disorders, arthritis, vision, depression, anxiety, Alzheimer's disease, Parkinson's disease, dementias, diabetes, coronary artery disease, kidney disease, viral or bacterial infections, and others. The composition can also be used to enhance the immune function of mammals and improve their energy levels. The composition can be used in combination with conventional chemotherapy to reduce side effects and speed up recovery. Overall, the composition can help reduce oxidative stress and improve the health of mammals.

Problems solved by technology

Mammals, including humans and their companion animals, are adversely affected by the oxidative stress.
Although treatment measures are available for canine neoplasia, these treatment measures are typically expensive and are not very effective.
In addition, while human therapies are often highly subsidized, the cost of treating service animals and pets generally falls wholly on the owners.
Medical expenses of this magnitude are likely to pose undue hardship on millions of people nationwide.

Method used

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  • Antioxidative stress compositions, methods of preparing and uses thereof
  • Antioxidative stress compositions, methods of preparing and uses thereof
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Examples

Experimental program
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example 1

[0079]This Example documents the first report to document oral administration of this schedule of combined chemopreventive agents in a canine study.

[0080]In enrolling canine pets as the subjects of the study, an objective was to perform a relatively short-term and non-invasive trial. Accordingly, lymphocytic DNA was used as a surrogate biomarker for oxidative stress. As described in the literature, this procedure has been used for assessing both the carcinogenic and anti-carcinogenic potential17 of test substances and, although lymphocytes are used for the observation, it may be surmised that other cell-types susceptible to carcinogenic insult could mount a similar response17. Since the ex vivo protective response of the lymphocyte is evaluated, and the chemopreventive agent is administered orally, it is logical to assume any positive response elicited by the agent would be through an indirect mechanism such as induction of cytoprotective enzymes. Thus, expression profiles with an a...

example 2

[0087]The development and production of a biscuit-type dosage form for relatively large canines presented some challenges since it was important to preserve the integrity of the chemopreventive agents. Thus, the common practice of baking the final product was avoided. During the development phase, many formulations were designed to form durable biscuit-type tablets and changes were made in an effort to reduce bellyband cracks and improve compressibility, compatibility, and flavour. The compaction of each active ingredient was individually tested, which revealed that the compounds themselves aid the compression of the tablets and helped balance the unfavourable compaction characteristics of the other biscuit ingredients.

[0088]Another issue that will ultimately be faced in developing a canine chemopreventive product is expense. Based on the quantities and price schedule for the chemopreventive agents purchased and used in this study, the expenditure was $1.65 / biscuit. It is difficult ...

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Abstract

Antioxidative stress compositions, methods of using antioxidative stress composition and methods of preparing antioxidative stress composition compositions are described. The antioxidative stress compositions may be chemopreventive and / or immunomodulatory. Resveratrol, genistein, ellagic acid, curcumin and quercetin may be included in the antioxidative stress composition compositions individually or in any combination.

Description

[0001]This application claims the benefit of U.S. Provisional Application No. 62 / 391,115, filed on Apr. 20, 2016, and U.S. Provisional Application No. 62 / 340,364, filed on May 23, 2016, both hereby incorporated by reference.BACKGROUND OF THE INVENTION[0002]Oxidation is a chemical reaction that can produce free radicals and can cause oxidative stress. Mammals, including humans and their companion animals, are adversely affected by the oxidative stress. The oxidative stress is therefore thought to be a source or a contributing factor of many disorders, including, e.g., aging, cancer, autoimmune disorders, heart disease, inflammatory disorders, bone disorders, bladder function disorders, joint health disorders, arthritis, vision, depression, anxiety, Alzheimer's disease, Parkinson's disease, dementias, diabetes, coronary artery disease, kidney disease, and viral or bacterial infections.[0003]In addition, since the average lifespan of a healthy non-human mammal (e.g., a canine) is short...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61K31/12A61K9/00A23K20/179A23K20/10A23K50/40A61K31/352A61K31/05
CPCA61K31/366A61K31/05A61K31/352A23K20/10A61K9/0056A23K50/40A23K20/179A61K31/12A61K45/06A23K50/42A61K2300/00
Inventor PEZZUTO, JOHN MICHAEL
Owner PEZZUTO JOHN MICHAEL
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