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Formulation

Pending Publication Date: 2021-10-14
OCUTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text explains that a medical device that comes in contact with biological fluids should have a higher contact angle and frictional properties to make it comfortable. Additionally, the text explains that using a specific formulation on the surface of the medical device can help reduce platelet aggregation, which can lead to complications. The technical effect of this patent text is to provide a more comfortable and effective medical device for contact with biological fluids.

Problems solved by technology

The higher the contact angle and the higher the frictional properties associated with the surface of a medical device designed for contact with a biological fluid, the less comfortable the medical device, both initially and following extended periods of contact.

Method used

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Examples

Experimental program
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Effect test

example 1

[0262]The following formulation was prepared according to the method provided below where:

[0263]To prepare 9 Litres of Saline

[0264]9 g—0.1 wt. % of propoxylated ethylenediamine compound according to Formula Ai having a number average molecular weight of 7200 (generally the compound sold under the trade name Tetronic® 90R4);

[0265]45 g—0.5 wt. % block copolymer of ethylene oxide and propylene oxide (PEG-PPG-PEG) having a number average molecular weight of 5800 (generally the compound sold under the trade name Pluronic® 123);

[0266]36 g—0.4 wt. % of Polyacrylic Acid (PAA) Sodium Salt having a number average molecular weight of 15000;

[0267]81 g—0.9 wt. % of Sodium Chloride;

[0268]9.9 g—0.1 wt. % of Boric Acid;

[0269]0.99 g—0.01 wt. % of Sodium di-Tertborate

[0270]0.45 g—0.005 wt % non-ionic, hydrophilic surfactant such as that sold under the trade name Poloxamer 407.

[0271]8910 mL of deionised water—98 wt %

[0272]1. Measure 946 ml of deionised water into the Duran bottle using a measuring cyl...

example 2

[0294]The following solutions were prepared:

[0295]Saline 6

[0296]To prepare 9 Litres of Saline B[0297]81 g of Sodium Chloride—0.89 wt %[0298]9.9 g of Boric Acid—0.11 wt %[0299]0.99 g of Sodium di-Tertborate—0.011 wt %[0300]0.45 g Poloxamer 407—0.005 wt %[0301]9000 mL of deionised water—99 wt %

[0302]Saline E

[0303]To prepare 9 Litres of Saline E[0304]9 g of Tetronic 90R4 (Mn 7200)—0.1 wt %[0305]45 g Pluronic 123 (Mn 5800)—0.5 wt %[0306]36 g of Polyacrylic acid Sodium Salt (Mw 15000)—0.4 wt %[0307]81 g of Sodium Chloride—0.9 wt %[0308]9.9 g of Boric Acid—0.1 wt %[0309]0.99 g of Sodium di-Tertborate—0.01 wt %[0310]0.45 g Poloxamer 407-0.005 wt %[0311]8910 mL of deionised water—98 wt %

[0312]Saline F

[0313]To prepare 9 Litres of Saline F[0314]9 g of Tetronic 1107 (Mn)—0.099 wt %[0315]45 g Pluronic 123 (Mn 5800)—0.49 wt %[0316]0.6750 g Hydroxpropylmethyl cellulose—0.0074 wt. %[0317]9 g polyvinylpyrrolidone—0.099 wt %[0318]54 g of Polyacrylic acid Sodium Salt (Mw 15000)—0.59 wt %[0319]75.95 g...

example 2a

[0330]Lenses were swollen in heptane for 1 h than transferred into Solution IV for 3 h and transferred and autoclaved in Saline F. The contact angle of the treated lenses was measured at room temperature. The mean contact angle of the treated lens was 18.2 with an associated standard deviation of 5.3.

TimeSampleSampleSampleSampleSampleSampleSampleSampleSampleSample(min)12345678910Untreated 82.379.954.382.579.190.981.184.381.265.4lens15 to 3013.413.368.728.714.620.416.215.122.514.5

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Abstract

There is disclosed a formulation suitable for the reduction or prevention of contamination of articles by microorganisms. The formulation includes at least one block copolymer of ethylene oxide and propylene oxide, at least one polyacrylic acid salt, and at least one propoxylated ethylenediamine compound.

Description

[0001]The present invention relates to a formulation and its use in increasing the biocompatibility of a medical device with its intended biological environment and body fluids, examples include but are not limited to cardiovascular and urological catheters, cardiovascular and urological stents, central venous catheters, thoracic drain and urological drainage catheters, hydrocephalic shunts and wound dressings. Body fluids include blood, tears, lymph, cerebral spinal fluid, saliva, extra cellular fluid. In addition, the present invention relates to formulations which can minimise thrombogenic, the spoliation of contact lenses, blockage of catheters[0002]There is also provided the use of the formulation of the present invention in the prevention or reduction of contamination of medical devices by microorganisms, and in the prevention or reduction of the formation of biofilms on a surface of an article such as a medical device.[0003]In addition, there is provided a method of increasin...

Claims

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Application Information

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IPC IPC(8): A61L12/12
CPCA61L12/12A61L29/085A61L27/34A61L27/50A61L29/14A61L31/10A61L31/14A61L2420/06A01N33/02A01N31/02A01N37/02A01N57/12C08L71/02C08K5/092A61L29/16A61L31/16A61L27/54A61L12/00A61L2/18A61K31/765A61K31/78A61K31/785A61P31/04A61L2202/24A61L15/225A61L15/42G02B1/043
Inventor BOWERS, RODERICKSWITNICKA-PLAK, MAGDELENAGRAHAM, NEILCARNEGIE, JAMESHONEYMAN, GORDONRASHID, ABDUL
Owner OCUTEC
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