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Medicinal inhalation devices and components thereof

a technology of inhalation device and component, which is applied in the direction of packaging foodstuffs, instruments, packaged goods, etc., can solve the problems of undesirable effects, adsorption of ambient water, and unsuitable material for a particular component, and achieve enhanced stability and/or resistance to attack, enhanced stability and resistance of the applied polyfluoropolyether-containing coating to attack, and flexural strength

Active Publication Date: 2012-01-31
KINDEVA DRUG DELIVERY LP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes a need for a coating system for medicinal inhalation devices that has desirable surface properties and structural integrity. The use of a monofunctional polyfluoropolyether silane and a non-fluorinated cross-linking agent has been found to provide high application efficiency and coverage, as well as extensive bonding to the surface of the device. The polyfluoropolyether segment should not be linked to silane groups via a functionality that includes a nitrogen-silicon bond or a sulfur-silicon bond for enhanced stability and resistance to attack. The polyfluoropolyether segment should also have a weight average molecular weight of at least 1000 or higher for durability and minimizing potential bioaccumulation. The patent also describes a method for applying a thin polyfluoropolyether-containing coating with desirable surface properties and structural integrity. The invention also includes devices and components made in accordance with the methods described.

Problems solved by technology

Often a desirable material for a particular component is found to be unsuitable in regard to its surface properties, e.g. surface energy, and / or its interaction with the medicinal formulation.
For DPIs often permeation and adsorption of ambient water pose issues.
Also the use of materials having relatively high surface energy for certain components (e.g. metered dose valves and / or individual components thereof), may have undesirable effects for the operation of movable components of a medicinal inhalation device.

Method used

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  • Medicinal inhalation devices and components thereof
  • Medicinal inhalation devices and components thereof
  • Medicinal inhalation devices and components thereof

Examples

Experimental program
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examples

Exemplary Silane Treatment Methods

[0164]The following are exemplary silane treatment methods:

Method A:

[0165]Place a solution (3 liters (L)) of 0.1% (w / w) C3F7O(CF(CF3)CF2O)pCF(CF3)—C(O)N(H)(CH2)3Si(OCH3)3 (average value of p is 10, average MW of silane is about 2151, and fraction of silane with a polyfluoropolyether segment having a weight average MW lower than 750 is zero), 0.6% (w / w) tetraethoxysilane and 1% (w / w) acetic acid in HFE-7200 fluid (available from 3M Company, St. Paul, Minn. under the trade designation “NOVEL HFE-7200”) in a 4-L beaker at room temperature, and place beaker in a dip coater. Fix component to be coated vertically above the solution, introduce component into the solution at a controlled rate of 15 millimeters per second (submerging the component entirely in the solution) and hold in place for at least five seconds. Subsequently withdrawn component from the solution at a controlled rate of 15 millimeters (mm) per second and allow to drain. After draining, p...

examples 1 to 3

[0169]Standard deep drawn aluminum MDI containers having a nominal volume of 10 milliliters are washed with trichloroethylene and coated in accordance with Method A (Example 1), Method B (Example 2) and Method C (Example 3), respectively. Containers are fitted with metered dose valves of the type marketed under the trade designation SPRAYMISER (3M Company, St. Paul, Minn., USA) having a 50 mcl metering chamber and then a formulation consisting of 1.97 mg / ml albuterol sulfate (having a majority of particles in the range of 1 to 3 microns) and HFA 134a is pressure-filled into the canisters.

examples 4 to 6

[0170]Standard deep drawn aluminum MDI containers having a volume of 10 millimeters are washed with trichloroethylene, anodized and coated in accordance with Method A (Example 4), Method B (Example 5) and Method C (Example 6), respectively. Containers are fitted with metered dose valves of the type marketed under the trade designation SPRAYMISER (3M Company, St. Paul, Minn., USA) having a 50 mcl metering chamber and then a formulation consisting of 1.97 mg / ml albuterol sulfate (having a majority of particles in the range of 1 to 3 microns) and HFA 134a is pressure-filled into the canisters.

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Abstract

A medicinal inhalation device having applied to surface thereof a composition comprising a monofunctional polyfluoropolyether silane and a non-fluorinated cross-linking agent.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a national stage filing under 35 U.S.C. 371 of PCT / US2008 / 082614, filed Nov. 6, 2008, which claims priority to Great Britain Application No. 0721739.1, filed Nov. 6, 2007, the disclosure of which is incorporated by reference in its / their entirety herein.FIELD OF THE INVENTION[0002]The present invention relates to medicinal inhalation devices and components for such devices as well as methods of making such devices and components.BACKGROUND OF THE INVENTION[0003]Medicinal inhalation devices, including pressurized inhalers, such as metered dose pressurized inhalers (MDIs), and dry powder inhalers (DPIs), are widely used for delivering medicaments.[0004]Medicinal inhalation devices typically comprise a plurality of hardware components, (which in the case of a MDI can include gasket seals; metered dose valves (including their individual components, such as ferrules, valve bodies, valve stems, tanks, springs retaining cups ...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61M15/00B05D1/00
CPCA61M15/009B65D83/48C08G65/007C08G65/336C08G65/3322Y10T428/265C08L2203/02Y10T428/31663Y10T428/31667
Inventor DAMS, RUDOLF J.
Owner KINDEVA DRUG DELIVERY LP
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