The invention discloses an industrialized multi-high-rise assembly type steel structure frame-pre-stressed center support system, belonging to the technical field of structural engineering, and comprising assembly type truss plates, assembly type flange posts and pre-stressed center support members, wherein the assembly type truss plates are prefabricated in a factory, and are mutually spliced through beam end sealing plates or post base nodes in a construction field to be used as frame structure beam and slab layers, the frame structure beam and slab layers are up and down connected through the assembly type flange posts to form a multi-layer steel frame structure; on the basis of the steel frame structure, the pre-stressed center support members are connected to the bottoms and the tops of posts or the truss beams in the frame structure beam and slab layers to be used as side force-resisting members; and the pre-stressed center support members are pre-fabricated in the factory, and are assembled by using bolts in the construction field. The invention integrates modularization, industrialization, standardization and assembly, realizes industrialized production and rapid field assembly, and has the advantages of increasing the construction speed, reducing the construction period and lowering the engineering cost under the premise of ensuring the construction quality.