The invention relates to the technical field of pharmaceutical preparations, in particular to a
folic acid tablet with low oxidation impurities and a preparation method thereof, and discloses the
folic acid tablet with low oxidation impurities, which comprises the following components: a mixture of
folic acid and an
antioxidant, a
porous starch; wherein the
mass ratio of the mixture of the folic acid and the
antioxidant to the
porous starch is (1-2): (3-4); the
mass ratio of the folic acid to the
antioxidant is 1: (1-3); the invention discloses a folic acid tablet with low oxidation impurities and a preparation method thereof, folic acid and an antioxidant tert-butylhydroquinone are mixed and crushed together, the folic acid can be fully wrapped by the antioxidant, oxidation of the folic acid is prevented or delayed, the particle size D90 of the mixture is controlled to be less than 5 [mu] m, then the mixture is fully mixed with
porous starch, and the folic acid tablet with low oxidation impurities is prepared. By utilizing the
porosity of the porous
starch, the folic acid and the antioxidant can be adsorbed in concave holes of the porous
starch, and meanwhile, the contact of the folic acid with
oxygen and light is reduced, so that the generation of oxidized impurities in the long-term placement process is reduced.