Dahurian rhododendron leaf extract and extracting method thereof

An extraction method, the technology of Manshanhong, is applied in the direction of medical formula, drug combination, plant raw materials, etc. It can solve the problems of inability to obtain exact characterization of high-purity extracts and high cream yields, and achieve good drug development prospects, convenient administration, and less toxic effect

Inactive Publication Date: 2007-08-29
李青山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The present invention aims at the problem that the high-purity extracts that cannot be accurately characterized at present, and thus Manshanhong is used as crude drug or crude extract as medicine, and provides a kind of Manshanhong (high purity) with exact characterization and outstanding effects in medicine Extract
[0009] The present invention also aims at the problems that the existing extracting method of mangosteen extract has a high paste yield and the obtained extracts are all crude extracts, and provides a method for extracting high-purity mangosteen extract

Method used

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  • Dahurian rhododendron leaf extract and extracting method thereof
  • Dahurian rhododendron leaf extract and extracting method thereof

Examples

Experimental program
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Embodiment 1

[0052] The preparation of embodiment 1. Manshanhong extract

[0053] 1. Extraction

[0054] Take the original medicinal material (300g of dry stems and leaves), pulverize, and extract 3 times (3000ml×3) with 3000ml of 40% ethanol aqueous solution under reflux at a temperature of 85°C-100°C, each time for 1hr, and combine the extracts, Stand overnight at room temperature, filter, remove precipitation, concentrate the filtrate under reduced pressure (55°C, 0.08-0.1MPa), to a total volume of 1800ml, add 540ml of 1% gelatin aqueous solution to the concentrated solution (equivalent to 5.4 grams of gelatin, can be made into other low concentration of gelatin aqueous solution, as long as the gelatin is fully dissolved), stirring, standing at room temperature for 4-8hr, suction filtration, discarding the residue, and passing the supernatant over a well-treated polyamide resin column (column volume about 400ml, flow rate 400ml / hr ), with a thin layer of polyamide sprayed with aluminum...

Embodiment 2

[0068] Embodiment 2. The preparation of Manshanhong extract

[0069] 1. Extraction

[0070] Get the original medicinal material (dried stem and leaf 300g) of Manshanhong different from example 1 in the place of production and harvest season, pulverize, and at a temperature of 85°C-100°C, reflux extract 3 times with 60% ethanol aqueous solution of 3000ml (3000ml×3 ), 1hr each time, combine the extracts, let stand overnight at room temperature, filter, remove precipitation, concentrate the filtrate under reduced pressure (55°C, 0.08-0.1MPa), to a total volume of 1800ml, add 270ml of 1% chitosan solution to the concentrate , stirred, then added 270ml of 1% gelatin aqueous solution, stirred, left standing at room temperature for 4-8hr, suction filtered, discarded the residue, and the supernatant was passed through the treated polyamide resin column overnight (column volume about 400ml, flow rate 400ml / hr), with The polyamide thin layer is sprayed with 95% aluminum chloride ethano...

Embodiment 3

[0084] Embodiment 3. The preparation of Manshanhong extract

[0085] 1. Extraction

[0086] Get the place of origin, harvesting season different from the original medicinal material (300g of dry stem and leaf) of Manshanhong different from example 1, 2, pulverize, under the temperature of 85 ℃-100 ℃, with the 60% ethanol aqueous solution reflux extraction of 3000ml 3 times (3000ml ×3), 1hr each time, combine the extracts, stand overnight at room temperature, filter, remove the precipitate, concentrate the filtrate under reduced pressure (55°C, 0.08-0.1MPa) to a total volume of 1800ml, add 1% ZTC1 type clarification to the concentrate Add 216ml of component B of the agent, stir, then add 108ml of component A of 1% ZTC type clarifier, stir, let stand at room temperature for 4-8hr, filter with suction, discard the residue, and pass the supernatant over the treated polyamide resin column (column volume About 400ml, flow rate 400ml / hr), spray polyamide thin layer with 95% aluminum...

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Abstract

The invention relates to the extracting process for Dahurian rhododendron leaf extract and extracting method, wherein the extract comprises, flavones 30-90% (measured by using hyperin as the representing compostion), hyperin compound 6.3-42%, farrerol 0.4-8%, quercetin compound 0.7-7%, the extraction method comprises employing polyamide resin separating column, clarifying the liquid with clearing agent and purifying.

Description

technical field [0001] The present invention relates to a Mangosteen extract and an extraction method thereof, in particular to a flavonoid extracted from Mangosteen and a method for extracting the flavonoid. Background technique [0002] Manshanhong is the dried leaf of Rhododendron dauricum L, a plant of Rhododendron family Rhododendron dauricum L, also known as Dazixiang, Yingshanhong, Yingshanhong and so on. It is a natural medicine with a wide range of pharmacological effects. The traditional Chinese medicine Manshanhong has the effects of relieving cough, eliminating phlegm, and relieving asthma. It is used to treat acute and chronic bronchitis and asthma. Its active ingredients are flavonoids. Among the Manshanhong products currently on the market, there are preparations that use Manshanhong crude drugs or crude extracts as medicines, such as "Manshanhong Oil Dropping Pills" and "Cough and Chin Syrup". The compound preparation with Manshanhong used as medicine has "...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/78A61K36/45A61P11/00A61K127/00A61K135/00
Inventor 李青山张振杰韩玲革李晓妮
Owner 李青山
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