Hydrothermal process of preparing nanometer hydroxyapatite colloid

A nano-hydroxyapatite, hydrothermal technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems such as affecting applications, particle agglomeration, and easy agglomeration of nanoparticles
CN100336719CActive Publication Date: 2007-09-12成都迪康中科生物医学材料有限公司
7 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
成都迪康中科生物医学材料有限公司
Publication Date
2007-09-12
Patent Text Reader

Abstract

The present invention discloses hydrothermal process of preparing nanometer hydroxyapatite colloid. The preparation process includes the following steps: 1. dissolving citrate of 0.774-309.6 weight portions and calcium salt of 1.64-262.6 weight portions in water of 200-5000 weight portions to compound solution A; 2. dissolving phosphate of 0.894-357.6 weight portions and forming Ca / P weight ration of 1.5-1.67 in water of 50-1200 weight portions to compound solution B; 3. heating solution A to 20-60 deg.c, preferably to 40-50 deg.c, and dropping solution B to solution A in 5-60 min; 4. heating after dropping to 60-100 deg.c while stirring to react for 2-6 hr to obtain nanometer hydroxyapatite colloid particles dispersed stably in water phase; and 5. ultrafiltering to eliminate salt from the nanometer hydroxyapatite colloid solution until reaching the filtrate conductivity of 20-200 microsecond / cm to obtain the purified nanometer hydroxyapatite colloid solution.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a method for preparing nano-hydroxyapatite colloid by a hydrothermal method, which belongs to the field of synthesis of nano-biological ceramics. Background technique

[0002] The main components of inorganic substances in human hard tissues (teeth and bones) are hydroxyapatite HA, calcium-deficient hydroxyapatite, fluorine-substituted hydroxyapatite, and carbonate-substituted hydroxyapatite. Therefore, from the perspective of bionics, it is best to use HA materials as human hard tissue replacement materials. Human bones are formed by the orderly deposition of nano-phase HA in the collagen matrix. Therefore, many studies at home and abroad tend to use nano-HA, collagen, polylactic acid (PLA), etc. as nanocomposite materials, and further use them as machinery and devices for bone repair and internal fixation of fractures, such as HA / PLA screws for internal fixation of fractures. However, due to the inherent agglomeration chara...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More