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Method for preparing transparent zinc hyaluronic acid

A technology of zinc hyaluronate and sodium hyaluronate, which is applied in the field of preparation of zinc hyaluronate, and can solve the problems of long production cycle, complex process, and low yield

Active Publication Date: 2007-12-19
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] There is a related patent in Hungary (Patent Publication No. 1086422) that reports the preparation process of HA-Zn powdered zinc hyaluronate, which is to dissolve sodium hyaluronate, add zinc salt, precipitate with an organic solvent, and then dehydrate and dry; The method used is to use ion exchange resin, first dissolve hyaluronic acid, put it on the ion exchange column, then alcohol precipitation, dehydration and drying, the common point of both is that it needs to be converted into a solution state, the production cycle is long, the process is complicated, and the yield is high. Low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Add 200 grams of sodium hyaluronate into 2 liters of alcohol solution containing 2% zinc acetate (45% alcohol), stir for 6 hours, let it stand, pour off the alcohol supernatant, and replace it 6 times in total. Dehydrate 5 times with 95% ethanol until the alcohol content is 93%, centrifuge to remove the ethanol, and dry in a vacuum oven until the moisture is 7%.

[0016] Test result: Viscosity: 21mm 2 / s, glucuronic acid content: 42.3%, zinc content 8.9%, sodium content: 0.2%.

Embodiment 2

[0018] Take 190 grams of sodium hyaluronate, stir, add 2 liters of 95% methanol containing 3% zinc sulfate, and start stirring. After 8 hours, stop stirring, pour off the methanol supernatant, repeat the above steps, and replace 8 times in total. Dehydrate with analytical pure methanol for 3 times, centrifuge to remove methanol, and dry in a vacuum oven until the water content reaches 7%.

[0019] Test result: Viscosity: 19mm 2 / s, glucuronic acid content: 43.1%, zinc content 6.2%, sodium content: 2.7%.

Embodiment 3

[0021] Add 150 grams of sodium hyaluronate to 2 liters of 95% ethanol solution containing 5% zinc chloride, stir for 10 hours, let stand, pour off the alcohol supernatant, repeat the above steps, and replace 8 times in total, and then use Analytical pure ethanol was dehydrated 5 times, centrifuged to remove alcohol, and dried in a vacuum oven until the water content reached 7%.

[0022] Test result: Viscosity: 23mm 2 / s, glucuronic acid content: 41.9%, zinc content 9.1%, sodium content: 0.2%.

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PUM

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Abstract

A process for preparing the zinc hyaluronate features the ionic exchange between sodium hyaluronate and Zn salt in alcohol solution.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals and relates to a preparation method of zinc hyaluronate. Background technique [0002] Zinc hyaluronate is the zinc salt of hyaluronic acid. Hyaluronic acid is a polysaccharide composed of disaccharide repeating units of glucuronic acid and glucosamine. It exists in the skin, vitreous body, umbilical cord, cartilage, In many connective tissues such as joint synovial fluid, it plays physiological functions such as moisturizing, nourishing, repairing and preventing damage. Zinc hyaluronate not only has the excellent performance of sodium hyaluronate, but also has anti-inflammatory and anti-ulcer effects. [0003] There is a related patent in Hungary (Patent Publication No. 1086422) that reports the preparation process of HA-Zn powdered zinc hyaluronate, which is to dissolve sodium hyaluronate, add zinc salt, precipitate with an organic solvent, and then dehydrate and dry; The method used is to use...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
Inventor 郭学平凌沛学刘爱华杨桂兰
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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