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Gadolinium-doped nanometer composite material, and its prepn. method

A nano-composite material and composite material technology, applied in the material field of MRI molecular imaging and molecular therapy research, can solve the problems of difficult differential diagnosis, lack of characteristic imaging performance, etc., and achieve enhanced relaxation rate and enhanced paramagnetism. , the effect of a wide range of application prospects

Inactive Publication Date: 2008-01-02
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the current clinical MRI diagnosis is mainly based on the tumor's gross morphological characteristics and tumor blood supply characteristics, and its imaging manifestations are not characteristic, and difficult differential diagnosis problems are often encountered in clinical work

Method used

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  • Gadolinium-doped nanometer composite material, and its prepn. method
  • Gadolinium-doped nanometer composite material, and its prepn. method
  • Gadolinium-doped nanometer composite material, and its prepn. method

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Example 1 Using the nonionic surfactant Pluronic P123 as a template and tetramethoxysilane as a silicon source to synthesize gadolinium-doped nanocomposites:

[0047] 2.3 millimoles of nonionic surfactant Pluronic P123 were dissolved in 30 milliliters of distilled water at 37 ° C, under ultrasonic vibration, Pluronic P123 was completely dissolved; then add 4 milliliters of concentrated hydrochloric acid (37%); continue to add 7 milliliters of mol tetramethoxysilane and 0.40 mmol GdCl 3 ·6H 2 O, the reaction was carried out for 7 minutes. Then, under ultrasonic vibration, the reaction solution was poured into 400 ml of 0.5 mol / L ammonia solution. The reaction was carried out for 20 minutes. The nanomaterials were collected by centrifugation (12000 rpm), dried at room temperature, and calcined at 300° C. for 4 hours to obtain the gadolinium-doped nanocomposite material. The obtained gadolinium-doped nanocomposite material has an average particle diameter of 34 nm, and...

Embodiment 2

[0048] Example 2 Using the nonionic surfactant Pluronic P123 as a template and tetraethoxysilane as a silicon source to synthesize gadolinium-doped nanocomposites:

[0049] 2.8 millimoles of nonionic surfactant Pluronic P123 were dissolved in 30 milliliters of distilled water at 37°C, under ultrasonic vibration, Pluronic P123 was completely dissolved; then 4 milliliters of concentrated hydrochloric acid (37%) was added; mol tetraethoxysilane and 0.30 mmol GdCl 3 ·6H 2 O, the reaction was carried out for 7 minutes. Then, under ultrasonic vibration, the reaction solution was poured into 500 ml of 0.5 mol / L ammonia solution. The reaction was carried out for 30 minutes. The nanomaterials were collected by centrifugation (12000 rpm), dried at room temperature, and calcined at 400°C for 4 hours to obtain the gadolinium-doped nanocomposite material. The obtained gadolinium-doped nanocomposite material is composed of particles with an average particle diameter of 38 nm, and the av...

Embodiment 3

[0050] Example 3 Synthesis of gadolinium-doped nanocomposites using nonionic surfactant Pluronic F127 as a template and tetramethoxysilane as a silicon source

[0051] 2.8 millimoles of nonionic surfactant Pluronic F127 were dissolved in 30 milliliters of distilled water at 37 ° C, under ultrasonic vibration, Pluronic F127 was completely dissolved; then add 4 milliliters of concentrated hydrochloric acid (37%); continue to add 7 milliliters of mol tetramethoxysilane and 0.30 mmol GdCl 3 ·6H 2 O, the reaction was carried out for 7 minutes. Then, under ultrasonic vibration, the reaction solution was poured into 600 ml of 0.5 mol / L ammonia solution. The reaction was carried out for 35 minutes. The nanomaterials were collected by centrifugation (12000 rpm), dried at room temperature, and calcined at 400°C for 4 hours to obtain the gadolinium-doped nanocomposite material. The material is composed of particles with an average diameter of 36nm, and the average diameter of the cha...

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Abstract

A Gd doped composite nano-material is proportionally prepared from Gd and silicon oxide, and feature sits (2-7)-nm channels, high p[aramagnetism of Gd, high relaxation rate of tissue T1 and T2, and high compatibility to biologic macromolecule. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a material used in MRI molecular imaging and molecular therapy research. Background technique [0002] MRI (Magnetic Resonance Imaging, MRI) is an advanced image examination technology developed in the 1980s. It uses the H protons in the human body to be excited by radio frequency pulses in a strong magnetic field to generate nuclear magnetic resonance phenomena. After spatial encoding technology, the nuclear magnetic resonance signals emitted in the form of electromagnetic reception are converted, and high-quality images are formed through the computer. MRI has the advantages of extremely high soft tissue resolution and no radiation damage. It has become one of the most important diagnostic tools and is widely used in clinic. [0003] The use of MRI contrast agents can enhance signal differences between tissues, revealing tiny lesions and lesions that resemble normal structures. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06
Inventor 李立郭刚军曾木圣
Owner SUN YAT SEN UNIV
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